Julian D Down
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Explore the profile of Julian D Down including associated specialties, affiliations and a list of published articles.
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29
Citations
800
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Recent Articles
11.
Down J, Medhora M, Jackson I, Cline J, Vujaskovic Z
Radiat Res
. 2013 Jul;
180(2):216-21.
PMID: 23819595
The role of mast cell infiltrates in the pathology of radiation damage to the lung has been a subject of continuing investigation over the past four decades. This has been...
12.
Jackson I, Xu P, Hadley C, Katz B, McGurk R, Down J, et al.
Health Phys
. 2012 Aug;
103(4):463-73.
PMID: 22929472
The purpose of preclinical murine model development is to establish that the pathophysiological outcome of the rodent model of radiation-induced lung injury is sufficiently representative of the anticipated pulmonary response...
13.
Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, et al.
Mol Ther
. 2011 Mar;
19(7):1273-86.
PMID: 21386821
A lentiviral vector encoding β-globin flanked by insulator elements has been used to treat β-thalassemia (β-Thal) successfully in one human subject. However, a clonal expansion was observed after integration in...
14.
Jackson I, Vujaskovic Z, Down J
Radiat Res
. 2011 Feb;
175(4):510-18.
PMID: 21338245
The human lung is among the most sensitive and critical tissues of concern in localized and systemic radiation exposures, and it is a subject of active preclinical research for evaluating...
15.
Dor F, Ramirez M, Down J, Cooper D
Transplantation
. 2010 Nov;
90(9):1040-1.
PMID: 21037464
No abstract available.
16.
Down J, Yanch J
Radiat Res
. 2010 Aug;
174(2):258-63.
PMID: 20681792
Pulmonary tissue is sensitive and often treatment-limiting in patients exposed to total-body irradiation (TBI) in preparation for hematopoietic stem cell transplantation. Many rodent strains, however, exhibit a relatively high resistance...
17.
Jackson I, Vujaskovic Z, Down J
Radiat Res
. 2010 Jan;
173(1):10-20.
PMID: 20041755
The mouse has been used extensively to model radiation injury to the lung, a major dose-limiting organ for radiotherapy. Substantial differences in the timing and sensitivity of this tissue between...
18.
Parmar K, Mauch P, Vergilio J, Sackstein R, Down J
Proc Natl Acad Sci U S A
. 2007 Mar;
104(13):5431-6.
PMID: 17374716
The interaction of stem cells with their bone marrow microenvironment is a critical process in maintaining normal hematopoiesis. We applied an approach to resolve the spatial organization that underlies these...
19.
Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human
Dor F, Ramirez M, Parmar K, Altman E, Huang C, Down J, et al.
Exp Hematol
. 2006 Oct;
34(11):1573-82.
PMID: 17046577
Objective: We previously observed high levels (>40%) of multilineage hematopoietic cell chimerism following spleen transplantation across full MHC barriers in immunosuppressed miniature swine. We therefore investigated the spleen as a...
20.
Ploemacher R, Johnson K, Rombouts E, Etienne K, Westerhof G, Baumgart J, et al.
Biol Blood Marrow Transplant
. 2004 Apr;
10(4):236-45.
PMID: 15077222
Treosulfan (L-threitol-1,4-bismethanesulfonate) is an alkylating agent with routine clinical application in the treatment of ovarian cancer. In this murine study we show that this drug also has the ability to...