Julia Joung
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Explore the profile of Julia Joung including associated specialties, affiliations and a list of published articles.
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33
Citations
11418
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Recent Articles
21.
Joung J, Engreitz J, Konermann S, Abudayyeh O, Verdine V, Aguet F, et al.
Nature
. 2017 Sep;
549(7672):418.
PMID: 28933431
This corrects the article DOI: 10.1038/nature23451.
22.
Joung J, Engreitz J, Konermann S, Abudayyeh O, Verdine V, Aguet F, et al.
Nature
. 2017 Aug;
548(7667):343-346.
PMID: 28792927
Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs (lncRNAs), some of which are known to carry out critical roles in diverse cellular processes through a variety of...
23.
Gootenberg J, Abudayyeh O, Lee J, Essletzbichler P, Dy A, Joung J, et al.
Science
. 2017 Apr;
356(6336):438-442.
PMID: 28408723
Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (previously known...
24.
Joung J, Konermann S, Gootenberg J, Abudayyeh O, Platt R, Brigham M, et al.
Nat Protoc
. 2017 Mar;
12(4):828-863.
PMID: 28333914
Forward genetic screens are powerful tools for the unbiased discovery and functional characterization of specific genetic elements associated with a phenotype of interest. Recently, the RNA-guided endonuclease Cas9 from the...
25.
Sanjana N, Wright J, Zheng K, Shalem O, Fontanillas P, Joung J, et al.
Science
. 2016 Oct;
353(6307):1545-1549.
PMID: 27708104
The noncoding genome affects gene regulation and disease, yet we lack tools for rapid identification and manipulation of noncoding elements. We developed a CRISPR screen using ~18,000 single guide RNAs...
26.
Chung W, Verghese P, Chakraborty C, Joung J, Hyman B, Ulrich J, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(36):10186-91.
PMID: 27559087
The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans, E2, E3, and E4. The presence...
27.
Abudayyeh O, Gootenberg J, Konermann S, Joung J, Slaymaker I, Cox D, et al.
Science
. 2016 Jun;
353(6299):aaf5573.
PMID: 27256883
The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference. We characterize the class 2 type...
28.
Dahlman J, Abudayyeh O, Joung J, Gootenberg J, Zhang F, Konermann S
Nat Biotechnol
. 2016 Apr;
34(4):441.
PMID: 27054997
No abstract available.
29.
Shmakov S, Abudayyeh O, Makarova K, Wolf Y, Gootenberg J, Semenova E, et al.
Mol Cell
. 2015 Nov;
60(3):385-97.
PMID: 26593719
Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, only two Class 2 effectors, Cas9 and Cpf1, are known....
30.
Dahlman J, Abudayyeh O, Joung J, Gootenberg J, Zhang F, Konermann S
Nat Biotechnol
. 2015 Oct;
33(11):1159-61.
PMID: 26436575
We have developed a CRISPR-based method that uses catalytically active Cas9 and distinct single guide (sgRNA) constructs to knock out and activate different genes in the same cell. These sgRNAs,...