Juin Fok-Seang
Overview
Explore the profile of Juin Fok-Seang including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
128
Followers
0
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Recent Articles
1.
Schmoele-Thoma B, Zareba A, Jiang Q, Maddur M, Danaf R, Mann A, et al.
N Engl J Med
. 2022 Jun;
386(25):2377-2386.
PMID: 35731653
Background: Although human respiratory syncytial virus (RSV) is an important cause of illness and death in older adults, no RSV vaccine has been licensed. Methods: In a phase 2a study,...
2.
Maas B, Lommerse J, Plock N, Railkar R, Cheung S, Caro L, et al.
EBioMedicine
. 2021 Nov;
73:103651.
PMID: 34775220
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development...
3.
Stevens M, Rusch S, DeVincenzo J, Kim Y, Harrison L, Meals E, et al.
J Infect Dis
. 2018 Apr;
218(5):748-756.
PMID: 29684148
Background: Respiratory syncytial virus (RSV) disease has no effective treatment. JNJ-53718678 is a fusion inhibitor with selective activity against RSV. Methods: After confirmation of RSV infection or 5 days after...
4.
Blair W, Cao J, Fok-Seang J, Griffin P, Isaacson J, Jackson R, et al.
Antimicrob Agents Chemother
. 2009 Oct;
53(12):5080-7.
PMID: 19805571
A new small-molecule inhibitor class that targets virion maturation was identified from a human immunodeficiency virus type 1 (HIV-1) antiviral screen. PF-46396, a representative molecule, exhibits antiviral activity against HIV-1...
5.
Tran T, Adam F, Calo F, Fenwick D, Fok-Seang J, Gardner I, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(17):5250-5.
PMID: 19632839
The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36,...
6.
Williams D, Adam F, Fenwick D, Fok-Seang J, Gardner I, Hay D, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(17):5246-9.
PMID: 19620004
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by...