Tanya Parkinson
Overview
Explore the profile of Tanya Parkinson including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
586
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0
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Recent Articles
1.
Gomez-Gonzalez P, Gupta A, Drought L, Patel A, Okombo J, van der Watt M, et al.
Sci Adv
. 2024 Dec;
10(49):eadq1383.
PMID: 39642214
Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat...
2.
Mansour N, Paveley R, Gardner J, Bell A, Parkinson T, Bickle Q
PLoS Negl Trop Dis
. 2016 Apr;
10(4):e0004659.
PMID: 27128493
An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel...
3.
Lobo S, Scott A, Videira M, Winpenny D, Gardner M, Palmer M, et al.
Mol Microbiol
. 2015 Apr;
97(3):472-87.
PMID: 25908396
Haem is a life supporting molecule that is ubiquitous in all major kingdoms. In Staphylococcus aureus, the importance of haem is highlighted by the presence of systems both for the...
4.
Faria J, Moraes C, Song R, Pascoalino B, Lee N, Siqueira-Neto J, et al.
J Biomol Screen
. 2014 Oct;
20(1):70-81.
PMID: 25342146
Human African trypanosomiasis (HAT) is a vector-transmitted tropical disease caused by the protozoan parasite Trypanosoma brucei. High-throughput screening (HTS) of small-molecule libraries in whole-cell assays is one of the most...
5.
Lotharius J, Gamo-Benito F, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, et al.
Malar J
. 2014 Apr;
13:143.
PMID: 24731288
Background: Repositioning of existing drugs has been suggested as a fast track for developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that...
6.
Holler T, Parkinson T, Pryde D
Expert Opin Drug Discov
. 2013 Mar;
4(3):293-314.
PMID: 23489127
Background: Chronic hepatitis C virus (HCV) infection is a main cause of cirrhosis of the liver and hepatocellular carcinoma. The standard of care is a combination of pegylated interferon with...
7.
Pryde D, Tran T, Gardner I, Bright H, Stupple P, Galan S, et al.
Bioorg Med Chem Lett
. 2012 Dec;
23(3):827-33.
PMID: 23265891
Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a...
8.
Bell A, Mills J, Williams G, Brannigan J, Wilkinson A, Parkinson T, et al.
PLoS Negl Trop Dis
. 2012 May;
6(4):e1625.
PMID: 22545171
Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we...
9.
Macpherson J, Sidders B, Wieland S, Zhong J, Targett-Adams P, Lohmann V, et al.
PLoS One
. 2011 Nov;
6(10):e25584.
PMID: 22046242
Hepatitis C virus (HCV) is a global problem. To better understand HCV infection researchers employ in vitro HCV cell-culture (HCVcc) systems that use Huh-7 derived hepatoma cells that are particularly...
10.
Jones P, Pryde D, Tran T, Adam F, Bish G, Calo F, et al.
Bioorg Med Chem Lett
. 2011 Sep;
21(19):5939-43.
PMID: 21885277
The discovery of a series of highly potent and novel TLR7 agonist interferon inducers is described. Structure-activity relationships are presented, along with pharmacokinetic studies of a lead molecule from this...