Juergen Hescheler
Overview
Explore the profile of Juergen Hescheler including associated specialties, affiliations and a list of published articles.
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52
Citations
1545
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Recent Articles
1.
Wagh V, Nguemo F, Kiseleva Z, Mader R, Hescheler J, Mohl W
ESC Heart Fail
. 2023 Sep;
10(6):3559-3572.
PMID: 37752740
Aims: Mechanochemical signalling drives organogenesis and is highly conserved in mammal evolution. Regaining recovery in myocardial jeopardy by inducing principles linking cardiovascular therapy and clinical outcome has been the dream...
2.
Pryymachuk G, El-Awaad E, Piekarek N, Drebber U, Maul A, Hescheler J, et al.
Histochem Cell Biol
. 2022 Mar;
157(5):513-524.
PMID: 35229169
Animal models and clinical studies suggest an influence of angiotensin II (AngII) on the pathogenesis of liver diseases via the renin-angiotensin system. AngII application increases portal blood pressure, reduces bile...
3.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, et al.
EMBO Rep
. 2019 Mar;
20(4).
PMID: 30886000
Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved...
4.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo J, et al.
Cell Stem Cell
. 2018 Dec;
24(2):318-327.e8.
PMID: 30554961
Human protein-coding genes are often accompanied by divergently transcribed non-coding RNAs whose functions, especially in cell fate decisions, are poorly understood. Using an hESC-based cardiac differentiation model, we define a...
5.
Mohl W, Spitzer E, Mader R, Wagh V, Nguemo F, Milasinovic D, et al.
ESC Heart Fail
. 2018 Sep;
5(6):1176-1183.
PMID: 30230713
Aims: Cardiac repair has steered clinical attention and remains an unmet need, because available regenerative therapies lack robust mechanistic evidence. Pressure-controlled intermittent coronary sinus occlusion (PICSO), known to induce angiogenetic...
6.
Mkrtchyan G, Ucal M, Mullebner A, Dumitrescu S, Kames M, Moldzio R, et al.
Biochim Biophys Acta Bioenerg
. 2018 May;
1859(9):925-931.
PMID: 29777685
Background And Purpose: Based on the fact that traumatic brain injury is associated with mitochondrial dysfunction we aimed at localization of mitochondrial defect and attempted to correct it by thiamine....
7.
Mohl W, Henry T, Milasinovic D, Nguemo F, Hescheler J, Perin E
EuroIntervention
. 2017 Aug;
13(6):760-772.
PMID: 28844036
Clinical heart failure prevention and contemporary therapy often involve breaking the vicious cycle of global haemodynamic consequences of myocardial decay. The lack of effective regenerative therapies results in a primary...
8.
Peinkofer G, Hescheler J, Halbach M
J Vis Exp
. 2017 Jun;
(124).
PMID: 28605368
Murine cardiomyocytes have been extensively used for in vitro studies of cardiac physiology and new therapeutic strategies. However, multicellular preparations of dissociated cardiomyocytes are not representative of the complex in...
9.
Frank S, Aguirre A, Hescheler J, Kurian L
Front Cell Dev Biol
. 2016 Nov;
4:128.
PMID: 27882316
Our conception of the human genome, long focused on the 2% that codes for proteins, has profoundly changed since its first draft assembly in 2001. Since then, an unanticipatedly expansive...
10.
Iglesias-Garcia O, Baumgartner S, Macri-Pellizzeri L, Rodriguez-Madoz J, Abizanda G, Guruceaga E, et al.
Stem Cells Dev
. 2014 Oct;
24(4):484-96.
PMID: 25329043
Stem cell-derived cardiomyocytes (CMs) are often electrophysiologically immature and heterogeneous, which represents a major barrier to their in vitro and in vivo application. Therefore, the purpose of this study was...