Kurt Pfannkuche
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Explore the profile of Kurt Pfannkuche including associated specialties, affiliations and a list of published articles.
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52
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928
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Recent Articles
1.
Kuckelkorn C, Aksoy E, Stojanovic N, Oulahyane L, Ritter M, Pfannkuche K, et al.
Adv Healthc Mater
. 2025 Feb;
:e2403897.
PMID: 39943918
Cardiac in vitro models serve as promising platforms for physiological and pathological studies, drug testing, and regenerative medicine. This study hypothesizes that immobilizing cardiomyocytes derived from human induced pluripotent stem...
2.
Xu G, Fatima A, Breitbach M, Kuzmenkin A, Fugemann C, Ivanyuk D, et al.
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047520
Most cardiomyocytes (CMs) in the adult mammalian heart are either binucleated or contain a single polyploid nucleus. Recent studies have shown that polyploidy in CMs plays an important role as...
3.
Jahn P, Karger R, Soso Khalaf S, Hamad S, Peinkofer G, Sahito R, et al.
Biofabrication
. 2022 May;
14(3).
PMID: 35617928
Multicellular agglomerates in form of irregularly shaped or spherical clusters can recapitulate cell-cell interactions and are referred to as microtissues. Microtissues gain increasing attention in several fields including cardiovascular research....
4.
Hamad S, Derichsweiler D, Hescheler J, Pfannkuche K
Methods Mol Biol
. 2021 Oct;
2454:145-161.
PMID: 34664217
Human induced pluripotent stem cells (hiPSCs) can be expanded at limitless scale in vitro and give rise to various organotypic cells, cardiomyocytes (CMs) among them. Advanced protocols shape the differentiation...
5.
Philipp D, Holthaus M, Basoah V, Pfannkuche K, Suhr L, Wahlers T, et al.
Stem Cells Int
. 2021 Apr;
2021:8888575.
PMID: 33927770
Myocardial hypertrophy is present in many heart diseases, representing a strong predictor of adverse cardiovascular outcomes. Regarding therapeutic intervention, mesenchymal stem cells (MSCs) have been suggested to significantly reduce cardiac...
6.
Ozturk-Oncel M, Heras-Bautista C, Uzun L, Hur D, Hescheler J, Pfannkuche K, et al.
ACS Biomater Sci Eng
. 2021 Mar;
7(4):1539-1551.
PMID: 33724787
Cardiomyocytes, differentiated from induced pluripotent stem cells (iPSCs), have the potential to produce patient- and disease-specific pharmacological and toxicological platforms, in addition to their cardiac cell therapy applications. However, the...
7.
Burkert K, Taheri H, Hamad S, Oliverio M, Peinkofer G, Kornfeld J, et al.
Sci Rep
. 2021 Jan;
11(1):2391.
PMID: 33504837
Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine...
8.
Daliri K, Pfannkuche K, Garipcan B
Soft Matter
. 2021 Jan;
17(5):1156-1172.
PMID: 33427281
In vitro cell culture is commonly applied in laboratories around the world. Cultured cells are either of primary origin or established cell lines. Such transformed cell lines are increasingly replaced...
9.
Peinkofer G, Maass M, Pfannkuche K, Sachinidis A, Baldus S, Hescheler J, et al.
Stem Cell Res Ther
. 2021 Jan;
12(1):46.
PMID: 33419458
Background: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known whether the developmental stage influences their persistence...
10.
Holzel B, Pfannkuche K, Allner B, Allner H, Hescheler J, Derichsweiler D, et al.
Arch Toxicol
. 2020 Jul;
94(9):3265-3280.
PMID: 32700163
In vitro assessment of genotoxicity as an early warning tool for carcinogenicity mainly relies on recording cytogenetic damages (micronuclei, nucleoplasmic bridges) in tumour-derived mammalian cell lines like V79 or CHO....