Judith L Campbell
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Explore the profile of Judith L Campbell including associated specialties, affiliations and a list of published articles.
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59
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2812
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Recent Articles
41.
Jaszczur M, Flis K, Rudzka J, Kraszewska J, Budd M, Polaczek P, et al.
Genetics
. 2008 Feb;
178(2):633-47.
PMID: 18245343
Most replicases are multi-subunit complexes. DNA polymerase epsilon from Saccharomyces cerevisiae is composed of four subunits: Pol2p, Dpb2p, Dpb3p, and Dpb4p. Pol2p and Dpb2p are essential. To investigate a possible...
42.
Reis C, Campbell J
Genetics
. 2006 Dec;
175(3):993-1010.
PMID: 17179095
Balanced levels of histones are crucial for chromosome stability, and one major component of this control regulates histone mRNA amounts. The Saccharomyces cerevisiae poly(A) polymerases Trf4 and Trf5 are involved...
43.
Boronat S, Campbell J
Mol Cell Biol
. 2006 Nov;
27(3):1158-71.
PMID: 17130241
Ectopic expression of Cdc6p results in mitotic delay, and this has been attributed to Cdc6p-mediated inhibition of Cdc28 protein kinase and failure to activate the anaphase-promoting complex (APC). Here we...
44.
Stewart J, Campbell J, Bambara R
J Biol Chem
. 2006 Oct;
281(50):38565-72.
PMID: 17038322
Okazaki fragments contain an initiator RNA/DNA primer that must be removed before the fragments are joined. In eukaryotes, the primer region is raised into a flap by the strand displacement...
45.
Masuda-Sasa T, Polaczek P, Campbell J
J Biol Chem
. 2006 Oct;
281(50):38555-64.
PMID: 17032657
The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-dependent ATPase, 3' exo/endonuclease, and 5' exo/endonuclease. The enzyme is highly specific for structures containing single-stranded flaps adjacent to...
46.
Masuda-Sasa T, Imamura O, Campbell J
Nucleic Acids Res
. 2006 Apr;
34(6):1865-75.
PMID: 16595800
Yeast Dna2 helicase/nuclease is essential for DNA replication and assists FEN1 nuclease in processing a subset of Okazaki fragments that have long single-stranded 5' flaps. It is also involved in...
47.
Budd M, Reis C, Smith S, Myung K, Campbell J
Mol Cell Biol
. 2006 Mar;
26(7):2490-500.
PMID: 16537895
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence that Saccharomyces cerevisiae...
48.
Budd M, Tong A, Polaczek P, Peng X, Boone C, Campbell J
PLoS Genet
. 2005 Dec;
1(6):e61.
PMID: 16327883
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700...
49.
Kao H, Campbell J, Bambara R
J Biol Chem
. 2004 Sep;
279(49):50840-9.
PMID: 15448135
During cellular DNA replication the lagging strand is generated as discontinuous segments called Okazaki fragments. Each contains an initiator RNA primer that is removed prior to joining of the strands....
50.
Kao H, Veeraraghavan J, Polaczek P, Campbell J, Bambara R
J Biol Chem
. 2004 Jan;
279(15):15014-24.
PMID: 14747468
Short DNA segments designated Okazaki fragments are intermediates in eukaryotic DNA replication. Each contains an initiator RNA/DNA primer (iRNA/DNA), which is converted into a 5'-flap and then removed prior to...