Juan R de Los Toyos
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Explore the profile of Juan R de Los Toyos including associated specialties, affiliations and a list of published articles.
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20
Citations
372
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Recent Articles
1.
de Los Toyos J
Methods Mol Biol
. 2023 May;
2673:189-196.
PMID: 37258915
The accurate prediction of B cell epitopes is crucial for the design and development of vaccines, especially of those preventive for emerging pathogenic diseases. Preventive vaccines are mainly based on...
2.
Lorenzo-Gomez R, Casero-Alvarez A, Miranda-Castro R, Garcia-Ocana M, de Los Toyos J, de-Los-Santos-Alvarez N, et al.
Talanta
. 2022 Jan;
240:123196.
PMID: 34998145
Characterization of extracellular matrix (ECM) is becoming more and more important to decipher cancer progression. Constant remodeling results in ECM components degradation or unusual ECM accumulation that releases short fragments...
3.
Aptamers targeting a tumor-associated extracellular matrix component: The human mature collagen XIα1
Lorenzo-Gomez R, Miranda-Castro R, de Los Toyos J, de-Los-Santos-Alvarez N, Lobo-Castanon M
Anal Chim Acta
. 2021 Nov;
1189:339206.
PMID: 34815029
The extracellular matrix (ECM) plays an essential role in tumor progression and invasion through its continuous remodeling. The growth of most carcinomas is associated with an excessive collagen deposition that...
4.
Zhu K, Cai L, Cui C, de Los Toyos J, Anastassiou D
PLoS Comput Biol
. 2021 Jul;
17(7):e1009228.
PMID: 34283835
During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple...
5.
Fernando-Macias E, Fernandez-Garcia M, Garcia-Perez E, Porrero Guerrero B, Lopez-Arevalo C, Rodriguez-Uria R, et al.
PeerJ
. 2020 Jun;
8:e9045.
PMID: 32547853
Background: Colorectal cancer is the second leading cause of cancer death. Almost half of the patients present recurrence within 5 years after the treatment of the primary tumor, the majority,...
6.
Cima-Cabal M, Vazquez F, de Los Toyos J, Del Mar Garcia-Suarez M
Methods Mol Biol
. 2019 Apr;
1968:101-111.
PMID: 30929209
Western blot analysis is widely used for detecting protein expression, analysis of protein-protein interactions, and searching for new biomarkers. Also, it is a diagnostic tool used for detection of human...
7.
Vazquez-Villa F, Garcia-Ocana M, Galvan J, Garcia-Martinez J, Garcia-Pravia C, Menendez-Rodriguez P, et al.
Tumour Biol
. 2015 Mar;
36(4):2213-22.
PMID: 25761876
The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature collagen 11A1, an extracellular minor fibrillar collagen. Under regular conditions, this gene and its derived products...
8.
Galvan J, Garcia-Martinez J, Vazquez-Villa F, Garcia-Ocana M, Garcia-Pravia C, Menendez-Rodriguez P, et al.
BMC Cancer
. 2014 Nov;
14:867.
PMID: 25417197
Background: The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of...
9.
Fuentes-Martinez N, Garcia-Pravia C, Garcia-Ocana M, Menendez-Rodriguez P, Del Amo J, Suarez-Fernandez L, et al.
Histol Histopathol
. 2014 Jul;
30(1):87-93.
PMID: 25005174
Background: Our previous studies demonstrated the expression of procollagen11A1 in fibroblasts of pancreatic cancer desmoplasia and the lack of expression in fibroblasts of pancreatitis by means of the polyclonal antibody...
10.
Garcia-Pravia C, Galvan J, Gutierrez-Corral N, Solar-Garcia L, Garcia-Perez E, Garcia-Ocana M, et al.
PLoS One
. 2013 Nov;
8(10):e78327.
PMID: 24194920
Background: The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic cancer, but an antibody that specifically stains...