Juan D Alfonzo
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Explore the profile of Juan D Alfonzo including associated specialties, affiliations and a list of published articles.
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62
Citations
1278
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Recent Articles
1.
Lukes J, Speijer D, Zikova A, Alfonzo J, Hashimi H, Field M
Trends Parasitol
. 2023 Sep;
39(11):902-912.
PMID: 37679284
The African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause...
2.
Silveira dAlmeida G, Casius A, Henderson J, Knuesel S, Aphasizhev R, Aphasizheva I, et al.
RNA
. 2023 May;
29(8):1243-1254.
PMID: 37197826
Following transcription, tRNAs undergo a series of processing and modification events to become functional adaptors in protein synthesis. Eukaryotes have also evolved intracellular transport systems whereby nucleus-encoded tRNAs may travel...
3.
G Dolce L, Zimmer A, Tengo L, Weis F, Rubio M, Alfonzo J, et al.
Nat Commun
. 2022 Nov;
13(1):6737.
PMID: 36347890
The essential deamination of adenosine A to inosine at the wobble base is the individual tRNA modification with the greatest effects on mRNA decoding, empowering a single tRNA to translate...
4.
5.
Bertotti S, Fleming I, Camara M, Centeno Camean C, Carmona S, Aguero F, et al.
Biochem J
. 2022 Feb;
479(4):561-580.
PMID: 35136964
Adenosine-to-inosine conversion at position 34 (A34-to-I) of certain tRNAs is essential for expanding their decoding capacity. This reaction is catalyzed by the adenosine deaminase acting on tRNA (ADAT) complex, which...
6.
Dixit S, Kessler A, Henderson J, Pan X, Zhao R, Silveira dAlmeida G, et al.
Nucleic Acids Res
. 2021 Dec;
49(22):12986-12999.
PMID: 34883512
Every type of nucleic acid in cells undergoes programmed chemical post-transcriptional modification. Generally, modification enzymes use substrates derived from intracellular metabolism, one exception is queuine (q)/queuosine (Q), which eukaryotes obtain...
7.
Kowalinski E, Alfonzo J
Mol Cell
. 2021 Dec;
81(23):4765-4767.
PMID: 34861186
Schöller et al. (2021) discovered that METTL8, thought of as an mRNA modifier, is a tRNA-specific mitochondrial enzyme important for mitochondrial translation and function. Paradoxically, increased expression of METTL8 is...
8.
Das A, Alfonzo J, Accornero F
Wiley Interdiscip Rev RNA
. 2021 Oct;
13(4):e1700.
PMID: 34664402
Naturally occurring post-transcriptional chemical modifications serve critical roles in impacting RNA structure and function. More directly, modifications may affect RNA stability, intracellular transport, translational efficiency, and fidelity. The combination of...
9.
Alfonzo J, Brown J, Byers P, Cheung V, Maraia R, Ross R
Nat Genet
. 2021 Jul;
53(8):1113-1116.
PMID: 34267373
No abstract available.
10.
Kulkarni S, Rubio M, Hegedusova E, Ross R, Limbach P, Alfonzo J, et al.
Nucleic Acids Res
. 2021 Jul;
49(14):8247-8260.
PMID: 34244755
Transfer RNAs (tRNAs) are key players in protein synthesis. To be fully active, tRNAs undergo extensive post-transcriptional modifications, including queuosine (Q), a hypermodified 7-deaza-guanosine present in the anticodon of several...