Juan Amaral
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Explore the profile of Juan Amaral including associated specialties, affiliations and a list of published articles.
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25
Citations
951
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Recent Articles
1.
Barone F, Bunea I, Creel K, Sharma R, Amaral J, Maminishkis A, et al.
Transl Vis Sci Technol
. 2024 Mar;
13(3):8.
PMID: 38470318
Purpose: The aim of this study was to develop and validate a test to assess visual function in pigs using the visual psychophysics contrast sensitivity function. Methods: We utilized a...
2.
Barone F, Amaral J, Bunea I, Farnoodian M, Gupta R, Gupta R, et al.
JCI Insight
. 2023 Jun;
8(11).
PMID: 37288665
Over 30 million people worldwide suffer from untreatable vision loss and blindness associated with childhood-onset and age-related eye diseases caused by photoreceptor (PR), retinal pigment epithelium (RPE), and choriocapillaris (CC)...
3.
Ripolles-Garcia A, Dolgova N, Phillips M, Savina S, Ludwig A, Stuedemann S, et al.
Stem Cell Reports
. 2022 Jul;
17(8):1824-1841.
PMID: 35905738
Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to...
4.
Sharma R, George A, Nimmagadda M, Ortolan D, Karla B, Qureshy Z, et al.
Nat Commun
. 2021 Dec;
12(1):7293.
PMID: 34911940
Age-related Macular Degeneration (AMD), a blinding eye disease, is characterized by pathological protein- and lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE) and atrophy of the RPE monolayer in...
5.
Stanzel B, Ader M, Liu Z, Amaral J, Aguirre L, Rickmann A, et al.
Adv Exp Med Biol
. 2019 Oct;
1186:141-170.
PMID: 31654389
Developing successful surgical strategies to deliver cell therapeutics to the back of the eye is an essential pillar to success for stem cell-based applications in blinding retinal diseases. Within this...
6.
Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al.
Elife
. 2019 Jan;
8.
PMID: 30666961
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration...
7.
Sharma R, Khristov V, Rising A, Jha B, Dejene R, Hotaling N, et al.
Sci Transl Med
. 2019 Jan;
11(475).
PMID: 30651323
Considerable progress has been made in testing stem cell-derived retinal pigment epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD). However, the recent reports of oncogenic mutations in...
8.
Ikeuchi T, de Vega S, Forcinito P, Doyle A, Amaral J, Rodriguez I, et al.
Sci Rep
. 2018 Dec;
8(1):17654.
PMID: 30518776
Angiogenesis is crucial for tissue development and homeostasis; however, excessive angiogenesis can lead to diseases, including arthritis and cancer metastasis. Some antiangiogenic drugs are available, but side effects remain problematic....
9.
Khristov V, Maminishkis A, Amaral J, Rising A, Bharti K, Miller S
Adv Exp Med Biol
. 2018 May;
1074:633-640.
PMID: 29721997
Previous work suggests that replacing diseased Retinal Pigment Epithelium (RPE) with a healthy autologous RPE sheet can provide vision rescue for AMD patients. We differentiated iPSCs into RPE using a...
10.
Mead B, Amaral J, Tomarev S
Invest Ophthalmol Vis Sci
. 2018 Feb;
59(2):702-714.
PMID: 29392316
Purpose: To investigate the benefit of bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (sEV) as an intravitreal (ivit) therapy in two rat models of glaucoma and to determine...