Ignacio R Rodriguez
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Explore the profile of Ignacio R Rodriguez including associated specialties, affiliations and a list of published articles.
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23
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917
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Recent Articles
1.
Ikeuchi T, de Vega S, Forcinito P, Doyle A, Amaral J, Rodriguez I, et al.
Sci Rep
. 2018 Dec;
8(1):17654.
PMID: 30518776
Angiogenesis is crucial for tissue development and homeostasis; however, excessive angiogenesis can lead to diseases, including arthritis and cancer metastasis. Some antiangiogenic drugs are available, but side effects remain problematic....
2.
Indaram M, Ma W, Zhao L, Fariss R, Rodriguez I, Wong W
Sci Rep
. 2015 Mar;
5:9144.
PMID: 25775051
Age-related macular degeneration (AMD) has been associated with both accumulation of lipid and lipid oxidative products, as well as increased neuroinflammatory changes and microglial activation in the outer retina. However,...
3.
Shi G, Chen S, Wandu W, Ogbeifun O, Nugent L, Maminishkis A, et al.
Invest Ophthalmol Vis Sci
. 2015 Feb;
56(3):1658-64.
PMID: 25678688
Purpose: The inflammatory process plays a major role in the pathogenesis of AMD, and recent data indicate the involvement of inflammasomes. Inflammasomes are intracellular structures that trigger inflammation by producing...
4.
Lee J, Huang J, Rodriguez I
Biochim Biophys Acta
. 2015 Jan;
1851(5):605-19.
PMID: 25617738
Accumulation of 7-ketocholesterol (7KCh) in tissues has been previously associated with various chronic aging diseases. Orally ingested 7KCh is readily metabolized by the liver and does not pose a toxicity...
5.
Rodriguez I, Clark M, Lee J, Curcio C
Exp Eye Res
. 2014 Sep;
128:151-5.
PMID: 25261634
We analyzed by LCMS lipid extracts of lens, retina (MNR) and RPE/Choroid (MPEC) from macaque monkeys 2-25 yr in age to determine their content of 7-ketocholesterol (7KCh) as function of...
6.
Huang J, Amaral J, Lee J, Rodriguez I
PLoS One
. 2014 Jul;
9(7):e100985.
PMID: 25036103
The cholesterol oxide 7-ketocholesterol (7KCh) has been implicated in numerous age-related diseases such as atherosclerosis, Alzheimer's disease, Parkinson's disease, cancer and age-related macular degeneration. It is formed by the autooxidation...
7.
Wang M, Wang X, Zhao L, Ma W, Rodriguez I, Fariss R, et al.
J Neurosci
. 2014 Mar;
34(10):3793-806.
PMID: 24599476
Chronic retinal inflammation in the form of activated microglia and macrophages are implicated in the etiology of neurodegenerative diseases of the retina, including age-related macular degeneration, diabetic retinopathy, and glaucoma....
8.
Amaral J, Lee J, Chou J, Campos M, Rodriguez I
PLoS One
. 2013 Feb;
8(2):e56099.
PMID: 23409131
Accumulation of 7-Ketocholesterol (7KCh) in lipid deposits has been implicated in a variety of chronic diseases including atherosclerosis, Alzheimer's disease and age-related macular degeneration. 7KCh is known to be pro-inflammatory...
9.
Huang J, Amaral J, Lee J, Larrayoz I, Rodriguez I
Biochim Biophys Acta
. 2012 Feb;
1821(4):637-46.
PMID: 22342272
Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related...
10.
Friedman J, Chang B, Krauth D, Lopez I, Waseem N, Hurd R, et al.
Proc Natl Acad Sci U S A
. 2010 Aug;
107(35):15523-8.
PMID: 20713727
Retinal degenerative diseases, such as retinitis pigmentosa and Leber congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the quality of life of affected individuals and...