Josiah E Hardesty
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Explore the profile of Josiah E Hardesty including associated specialties, affiliations and a list of published articles.
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31
Citations
538
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Recent Articles
1.
Gripshover T, Treves R, Rouchka E, Chariker J, Zheng S, Hudson E, et al.
Alcohol Clin Exp Res (Hoboken)
. 2024 Nov;
49(1):106-116.
PMID: 39592394
Background: Alcohol-associated hepatitis (AH) is the clinical manifestation of alcohol-associated liver disease (ALD). AH is a complex disease encompassing the dysregulation of many cells and cell subpopulations. This study used...
2.
Bolatimi O, Hua Y, Ekuban F, Gripshover T, Ekuban A, Luulay B, et al.
Environ Int
. 2024 Nov;
194:109152.
PMID: 39577358
"Dioxins" are persistent organic pollutants (POPs) that are continuously present in the environment at appreciable levels and have been associated with increased risk of steatotic liver disease (SLD). However, current...
3.
Hardesty J, McClain C
Clin Liver Dis
. 2024 Oct;
28(4):731-745.
PMID: 39362718
Patients with alcohol-associated liver disease (ALD) consume large amounts of empty calories and are at risk for malnutrition. Malnutrition can present with micro- or macro-nutrient deficiencies. The standard-of-care drug treatment...
4.
Hardesty J, Warner J, Wilkey D, Phinney B, Salemi M, Merchant M, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337294
Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying...
5.
Warner J, Hardesty J, Song Y, Floyd A, Deng Z, Jebet A, et al.
Am J Pathol
. 2023 Nov;
194(1):71-84.
PMID: 37925018
Alcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacologic options. The goal of the current study was to investigate the efficacy of pharmacologic inhibition of soluble...
6.
Hardesty J, Warner J, Song Y, Floyd A, McClain C, Warner D, et al.
Biology (Basel)
. 2023 May;
12(5).
PMID: 37237453
Alcohol-associated liver disease (ALD) is the most common chronic liver disease and carries a significant healthcare burden. ALD has no long-term treatment options aside from abstinence, and the mechanisms that...
7.
Hardesty J, Warner J, Song Y, Rouchka E, McClain C, Warner D, et al.
FASEB J
. 2022 Dec;
37(1):e22705.
PMID: 36520060
Alcohol-associated liver disease (ALD) is a major health problem with limited effective treatment options. Alcohol-associated hepatitis (AH) is a subset of severe ALD with a high rate of mortality due...
8.
Wu X, Fan X, McMullen M, Miyata T, Kim A, Pathak V, et al.
Hepatology
. 2022 Jun;
77(3):902-919.
PMID: 35689613
Background And Aims: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation...
9.
Warner J, Larsen I, Hardesty J, Song Y, Warner D, McClain C, et al.
Front Physiol
. 2022 Feb;
12:812882.
PMID: 35153819
Alcohol-associated liver disease (ALD) is a prevalent liver disorder and significant global healthcare burden with limited effective therapeutic options. The gut-liver axis is a critical factor contributing to susceptibility to...
10.
Jin J, Wahlang B, Thapa M, Head K, Hardesty J, Srivastava S, et al.
Acta Pharm Sin B
. 2022 Jan;
11(12):3806-3819.
PMID: 35024308
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation...