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Craig J McClain

Explore the profile of Craig J McClain including associated specialties, affiliations and a list of published articles. Areas
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Articles 285
Citations 7971
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Recent Articles
1.
Teng Y, Luo C, Qiu X, Mu J, Sriwastva M, Xu Q, et al.
Nat Commun . 2025 Feb; 16(1):1295. PMID: 39900923
Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate the impact...
2.
Lei C, Luo C, Xu Z, Ding S, Sriwastva M, Dryden G, et al.
Nat Microbiol . 2024 Dec; 10(1):126-143. PMID: 39690194
Inflammatory bowel disease is associated with several genetic risk loci. Loss-of-function mutation in the α1,2-fucosyltransferase (fut2) gene, which alters fucosylation on the surface of intestinal epithelial cells, is one example....
3.
Gripshover T, Treves R, Rouchka E, Chariker J, Zheng S, Hudson E, et al.
Alcohol Clin Exp Res (Hoboken) . 2024 Nov; 49(1):106-116. PMID: 39592394
Background: Alcohol-associated hepatitis (AH) is the clinical manifestation of alcohol-associated liver disease (ALD). AH is a complex disease encompassing the dysregulation of many cells and cell subpopulations. This study used...
4.
Xu M, Taylor M, Hill B, Li X, Rouchka E, McClain C, et al.
Hepatol Commun . 2024 Nov; 8(12). PMID: 39585307
Background: Intestine epithelial hypoxia-inducible factor-1α (HIF-1α) plays a critical role in maintaining gut barrier function. The aim of this study was to determine whether pharmacological or genetic activation of intestinal...
5.
He L, Xu R, Ma X, Yin X, Mueller E, Feng W, et al.
J Proteome Res . 2024 Oct; 23(11):4962-4972. PMID: 39418671
Metabolic dysfunction in the liver represents a predominant feature in the early stages of alcohol-associated liver disease (ALD). However, the mechanisms underlying this are only partially understood. To investigate the...
6.
Brown K, Funk K, Figueroa Barrientos A, Bailey A, Shrader S, Feng W, et al.
Cells . 2024 Oct; 13(19. PMID: 39404382
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that exists in the plant. CBD has been found to act on various receptors, including both cannabinoid and non-cannabinoid receptors. In addition, CBD...
7.
Hardesty J, McClain C
Clin Liver Dis . 2024 Oct; 28(4):731-745. PMID: 39362718
Patients with alcohol-associated liver disease (ALD) consume large amounts of empty calories and are at risk for malnutrition. Malnutrition can present with micro- or macro-nutrient deficiencies. The standard-of-care drug treatment...
8.
Hardesty J, Warner J, Wilkey D, Phinney B, Salemi M, Merchant M, et al.
Int J Mol Sci . 2024 Sep; 25(18). PMID: 39337294
Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying...
9.
Chilton P, Ghare S, Charpentier B, Myers S, Rao A, Petrosino J, et al.
Gut Microbes . 2024 Aug; 16(1):2389319. PMID: 39182227
Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer's disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology...
10.
Gobejishvili L, McClain C
Hepatology . 2024 Aug; PMID: 39116338
No abstract available.