Joshua R Porter
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Explore the profile of Joshua R Porter including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
387
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Recent Articles
1.
Footer K, Lake C, Porter J, Ha G, Ahmed T, Glogowski A, et al.
JAMIA Open
. 2024 Jul;
7(3):ooae069.
PMID: 39044942
Objectives: Public sharing of de-identified biomedical data promotes collaboration between researchers and accelerates the development of disease prevention and treatment strategies. However, open-access data sharing presents challenges to researchers who...
2.
Woo Seuk Koh , Porter J, Batchelor E
Sci Rep
. 2019 Apr;
9(1):5976.
PMID: 30979970
Synthetic biological circuits that can generate outputs with distinct expression dynamics are useful for a variety of biomedical and industrial applications. We present a method to control output dynamics by...
3.
Hanson R, Porter J, Batchelor E
J Cell Biol
. 2019 Feb;
218(4):1282-1297.
PMID: 30745421
In response to DNA damage, the transcription factor p53 accumulates in a series of pulses. While p53 dynamics play a critical role in regulating stress responses, how p53 pulsing affects...
4.
Porter J, Fisher B, Baranello L, Liu J, Kambach D, Nie Z, et al.
Mol Cell
. 2017 Sep;
67(6):1013-1025.e9.
PMID: 28867293
In response to stresses, cells often halt normal cellular processes, yet stress-specific pathways must bypass such inhibition to generate effective responses. We investigated how cells redistribute global transcriptional activity in...
5.
Porter J, Telford W, Batchelor E
J Vis Exp
. 2017 Mar;
(120).
PMID: 28287544
Gene expression measurements from bulk populations of cells can obscure the considerable transcriptomic variation of individual cells within those populations. Single-cell gene expression measurements can help assess the role of...
6.
Porter J, Fisher B, Batchelor E
Cell Syst
. 2016 May;
2(4):272-82.
PMID: 27135539
The transcription factor p53 responds to DNA double-strand breaks by increasing in concentration in a series of pulses of fixed amplitude, duration, and period. How p53 pulses influence the dynamics...
7.
Porter J, Batchelor E
Methods Mol Biol
. 2014 Dec;
1244:259-76.
PMID: 25487101
This chapter describes approaches for using computational modeling of synthetic biology perturbations to analyze endogenous biological circuits, with a particular focus on signaling and metabolic pathways. We describe a bottom-up...
8.
Porter J, Lee C, Espenshade P, Iglesias P
Mol Biol Cell
. 2012 Jul;
23(18):3764-74.
PMID: 22833559
Cells adapt to changes in ambient oxygen by changing their gene expression patterns. In fission yeast, the sterol regulatory element-binding protein Sre1 is proteolytically cleaved under low oxygen, and its...
9.
Porter J, Andrews B, Iglesias P
Integr Biol (Camb)
. 2012 Feb;
4(3):310-7.
PMID: 22370552
Cells make many binary (all-or-nothing) decisions based on noisy signals gathered from their environment and processed through noisy decision-making pathways. Reducing the effect of noise to improve the fidelity of...
10.
Porter J, Burg J, Espenshade P, Iglesias P
J Theor Biol
. 2012 Feb;
300:232-41.
PMID: 22310068
When part of a biological system cannot be investigated directly by experimentation, we face the problem of structure identification: how can we construct a model for an unknown part of...