Joshua M Shulman
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Explore the profile of Joshua M Shulman including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Ye H, Robak L, Yu M, Cykowski M, Shulman J
Annu Rev Pathol
. 2022 Sep;
18:95-121.
PMID: 36100231
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous, resisting distillation to a single, cohesive disorder. Instead, each affected individual develops a virtually unique form of Parkinson's syndrome. Clinical manifestations...
12.
Ye F, Funk Q, Rockers E, Shulman J, Masdeu J, Pascual B
Brain Commun
. 2022 Sep;
4(5):fcac216.
PMID: 36092303
Neuroimaging in the preclinical phase of Alzheimer's disease provides information crucial to early intervention, particularly in people with a high genetic risk. Metabolic network modularity, recently applied to the study...
13.
Hill E, Robak L, Al-Ouran R, Deger J, Fong J, Vandeventer P, et al.
Neurol Genet
. 2022 Jun;
8(4):e200002.
PMID: 35747619
Background And Objectives: Genetic variants affect both Parkinson disease (PD) risk and manifestations. Although genetic information is of potential interest to patients and clinicians, genetic testing is rarely performed during...
14.
Alfradique-Dunham I, Al-Ouran R, von Coelln R, Blauwendraat C, Hill E, Luo L, et al.
Neurol Genet
. 2021 May;
7(2):e557.
PMID: 33987465
Objective: To discover genetic determinants of Parkinson disease (PD) motor subtypes, including tremor dominant (TD) and postural instability/gait difficulty (PIGD) forms. Methods: In 3,212 PD cases of European ancestry, we...
15.
Abreha M, Ojelade S, Dammer E, McEachin Z, Duong D, Gearing M, et al.
J Biol Chem
. 2021 May;
296:100760.
PMID: 33965374
One of the defining pathological features of Alzheimer's disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD...
16.
Petyuk V, Yu L, Olson H, Yu F, Clair G, Qian W, et al.
J Proteome Res
. 2021 Apr;
20(5):2266-2282.
PMID: 33900085
Proteinaceous aggregates containing α-synuclein protein called Lewy bodies in the substantia nigra is a hallmark of Parkinson's disease. The molecular mechanisms of Lewy body formation and associated neuronal loss remain...
17.
Guo Q, Dammer E, Zhou M, Kundinger S, Gearing M, Lah J, et al.
Front Mol Neurosci
. 2021 Apr;
14:623659.
PMID: 33815056
Core spliceosome and related RNA-binding proteins aggregate in Alzheimer's disease (AD) brain even in early asymptomatic stages (AsymAD) of disease. To assess the specificity of RNA-binding protein aggregation in AD,...
18.
Bailey M, Shulman L, Ryan D, Ouyang B, Shulman J, Buchman A, et al.
J Gerontol A Biol Sci Med Sci
. 2021 Feb;
76(7):1340-1345.
PMID: 33631006
Background: There is paucity of data about African American (AA) patients with Parkinson's disease (PD) and parkinsonism which may precede PD in older adults. Prior studies suggest that there are...
19.
Hill E, Mangleburg C, Alfradique-Dunham I, Ripperger B, Stillwell A, Saade H, et al.
Parkinsonism Relat Disord
. 2021 Feb;
84:105-111.
PMID: 33607526
Introduction: Emerging technologies show promise for enhanced characterization of Parkinson's Disease (PD) motor manifestations. We evaluated quantitative mobility measures from a wearable device compared to the conventional motor assessment, the...
20.
Yao T, Sweeney E, Nagorski J, Shulman J, Allen G
PLoS One
. 2020 Nov;
15(11):e0241707.
PMID: 33152028
Even though there is a clear link between Alzheimer's Disease (AD) related neuropathology and cognitive decline, numerous studies have observed that healthy cognition can exist in the presence of extensive...