Joshua M Gilmore
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Explore the profile of Joshua M Gilmore including associated specialties, affiliations and a list of published articles.
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28
Citations
1022
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0
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Recent Articles
1.
Sardiu M, Gilmore J, Groppe B, Dutta A, Florens L, Washburn M
Nat Commun
. 2019 Mar;
10(1):1118.
PMID: 30850613
It remains a significant challenge to define individual protein associations within networks where an individual protein can directly interact with other proteins and/or be part of large complexes, which contain...
2.
Vitorino F, Montoni F, Moreno J, de Souza B, Lopes M, Cordeiro B, et al.
Proteomics
. 2018 Jul;
18(17):e1800203.
PMID: 30035358
Fibroblast growth factor 2 (FGF2) is a well-known cell proliferation promoter; however, it can also induce cell cycle arrest. To gain insight into the molecular mechanisms of this antiproliferative effect,...
3.
Nemec C, Yang F, Gilmore J, Hintermair C, Ho Y, Tseng S, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(20):E3944-E3953.
PMID: 28465432
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) orchestrates dynamic recruitment of specific cellular machines during different stages of transcription. Signature phosphorylation patterns of...
4.
Sardiu M, Gilmore J, Groppe B, Florens L, Washburn M
Sci Rep
. 2017 Mar;
7:43845.
PMID: 28272416
Biological networks consist of functional modules, however detecting and characterizing such modules in networks remains challenging. Perturbing networks is one strategy for identifying modules. Here we used an advanced mathematical...
5.
Chromatin remodeller Fun30 induces nucleosome disassembly to facilitate RNA polymerase II elongation
Lee J, Choi E, Seo H, Kang K, Gilmore J, Florens L, et al.
Nat Commun
. 2017 Feb;
8:14527.
PMID: 28218250
Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo...
6.
Liang K, Volk A, Haug J, Marshall S, Woodfin A, Bartom E, et al.
Cell
. 2017 Jan;
168(1-2):59-72.e13.
PMID: 28065413
Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and...
7.
Brannan K, Jin W, Huelga S, Banks C, Gilmore J, Florens L, et al.
Mol Cell
. 2016 Oct;
64(2):282-293.
PMID: 27720645
RNA metabolism is controlled by an expanding, yet incomplete, catalog of RNA-binding proteins (RBPs), many of which lack characterized RNA binding domains. Approaches to expand the RBP repertoire to discover...
8.
Gilmore J, Sardiu M, Groppe B, Thornton J, Liu X, Dayebgadoh G, et al.
PLoS One
. 2016 Jun;
11(6):e0155492.
PMID: 27248496
Proteins that respond to DNA damage play critical roles in normal and diseased states in human biology. Studies have suggested that the S. cerevisiae protein CMR1/YDL156w is associated with histones...
9.
Weems J, Slaughter B, Unruh J, Hall S, McLaird M, Gilmore J, et al.
J Biol Chem
. 2015 Apr;
290(24):15030-41.
PMID: 25878247
Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3...
10.
Liang K, Gao X, Gilmore J, Florens L, Washburn M, Smith E, et al.
Mol Cell Biol
. 2015 Jan;
35(6):928-38.
PMID: 25561469
Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad repeat, both in vitro and...