Joshua J Gruber
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Explore the profile of Joshua J Gruber including associated specialties, affiliations and a list of published articles.
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27
Citations
1400
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Recent Articles
1.
Zhao Y, Andoh T, Charles F, Reddy P, Paul K, Goar H, et al.
bioRxiv
. 2025 Jan;
PMID: 39803490
VISTA is a key immune checkpoint receptor under investigation for cancer immunotherapy; however, its signaling mechanisms remain unclear. Here we identify a conserved four amino acid (NPGF) intracellular motif in...
2.
Nshanian M, Gruber J, Geller B, Chleilat F, Lancaster S, White S, et al.
Nat Metab
. 2025 Jan;
7(1):196-211.
PMID: 39789354
The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks....
3.
Li Y, Tan M, Akkari-Henic A, Zhang L, Kip M, Sun S, et al.
Nat Biomed Eng
. 2024 May;
8(7):890-908.
PMID: 38778183
The functions of non-coding regulatory elements (NCREs), which constitute a major fraction of the human genome, have not been systematically studied. Here we report a method involving libraries of paired...
4.
Nshanian M, Geller B, Gruber J, Chleilat F, Camarillo J, Kelleher N, et al.
Res Sq
. 2024 Feb;
PMID: 38410440
The short-chain fatty acids (SCFA) propionate and butyrate are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. In order to better...
5.
Rajkumar S, Dixon D, Lipchik A, Gruber J
J Vis Exp
. 2024 Feb;
203.
PMID: 38345235
HAT1, also known as Histone acetyltransferase 1, plays a crucial role in chromatin synthesis by stabilizing and acetylating nascent H4 before nucleosome assembly. It is required for tumor growth in...
6.
Nshanian M, Gruber J, Geller B, Chleilat F, Lancaster S, White S, et al.
bioRxiv
. 2024 Jan;
PMID: 38293216
The short-chain fatty acids (SCFA) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks....
7.
Li A, He B, Karagiannis D, Li Y, Jiang H, Srinivasan P, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2302489120.
PMID: 37695911
Loss of estrogen receptor (ER) pathway activity promotes breast cancer progression, yet how this occurs remains poorly understood. Here, we show that serine starvation, a metabolic stress often found in...
8.
Gaddameedi J, Chou T, Geller B, Rangarajan A, Swaminathan T, Dixon D, et al.
J Med Chem
. 2023 Apr;
66(8):5774-5801.
PMID: 37027002
HAT1 is a central regulator of chromatin synthesis that acetylates nascent histone H4. To ascertain whether targeting HAT1 is a viable anticancer treatment strategy, we sought to identify small-molecule inhibitors...
9.
Jiang H, Greathouse R, Tiche S, Zhao M, He B, Li Y, et al.
Cancer Res
. 2023 Jan;
83(2):346.
PMID: 36651077
No abstract available.
10.
Jiang H, Greathouse R, Tiche S, Zhao M, He B, Li Y, et al.
Cancer Res
. 2022 Nov;
83(2):181-194.
PMID: 36318118
Significance: Targeting cancer metabolism using the mitochondrial uncoupler niclosamide ethanolamine leads to methylome reprogramming and differentiation in neuroblastoma, providing a therapeutic opportunity to reverse the Warburg effect and suppress tumor...