Joshua A McCarroll
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Explore the profile of Joshua A McCarroll including associated specialties, affiliations and a list of published articles.
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32
Citations
992
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Recent Articles
11.
Kokkinos J, Ignacio R, Sharbeen G, Boyer C, Gonzales-Aloy E, Goldstein D, et al.
Biomaterials
. 2020 Feb;
240:119742.
PMID: 32088410
Pancreatic cancer is predicted to be the second leading cause of cancer-related death by 2025. The best chemotherapy only extends survival by an average of 18 weeks. The extensive fibrotic...
12.
Byrne F, Olzomer E, Marriott G, Quek L, Katen A, Su J, et al.
Redox Biol
. 2019 Nov;
28:101374.
PMID: 31743887
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical...
13.
Koach J, Holien J, Massudi H, Carter D, Ciampa O, Herath M, et al.
Cancer Res
. 2019 Sep;
79(21):5652-5667.
PMID: 31501192
MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a key component of MYCN oncogenesis and...
14.
Tjandra K, McCarthy N, Yang L, Laos A, Sharbeen G, Phillips P, et al.
J Med Chem
. 2019 Jul;
63(5):2181-2193.
PMID: 31347843
Medulloblastoma is a malignant brain tumor diagnosed in children. Chemotherapy has improved survival rates to approximately 70%; however, children are often left with long-term treatment side effects. New therapies that...
15.
McCarroll J, Sharbeen G, Kavallaris M, Phillips P
Methods Mol Biol
. 2019 May;
1974:329-353.
PMID: 31099013
Pancreatic cancer is a lethal malignancy which is refractory to most chemotherapy drugs. Recent landmark studies have shed new light on the complex genetic heterogeneity of pancreatic cancer and provide...
16.
Parker A, Teo W, Pandzic E, Vicente J, McCarroll J, Wordeman L, et al.
Life Sci Alliance
. 2018 Aug;
1(2).
PMID: 30079401
Microtubules are highly dynamic structures that play an integral role in fundamental cellular functions. Different α- and β-tubulin isotypes are thought to confer unique dynamic properties to microtubules. The tubulin...
17.
Sagnella S, Trieu J, Brahmbhatt H, MacDiarmid J, Macmillan A, Whan R, et al.
Mol Cancer Ther
. 2018 Mar;
17(5):1012-1023.
PMID: 29491149
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to improve treatment efficacy and...
18.
Parker A, Teo W, McCarroll J, Kavallaris M
Int J Mol Sci
. 2017 Jul;
18(7).
PMID: 28677634
Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular functions throughout all phases of the cell cycle. Altered tubulin isotype composition of microtubules is emerging as a feature...
19.
Teo J, McCarroll J, Boyer C, Youkhana J, Sagnella S, Duong H, et al.
Biomacromolecules
. 2016 Jun;
17(7):2337-51.
PMID: 27305597
Pancreatic cancer is a devastating disease with a dismal prognosis. Short-interfering RNA (siRNA)-based therapeutics hold promise for the treatment of cancer. However, development of efficient and safe delivery vehicles for...
20.
Parker A, Turner N, McCarroll J, Kavallaris M
Carcinogenesis
. 2016 May;
37(8):787-798.
PMID: 27207668
Non-small cell lung cancer (NSCLC) survival rates are dismal and high βIII-tubulin expression is associated with chemotherapy drug resistance and tumor aggressiveness in this disease. Mounting evidence supports a role...