Joshua A McCarroll
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Explore the profile of Joshua A McCarroll including associated specialties, affiliations and a list of published articles.
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32
Citations
992
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Recent Articles
1.
Ephraums J, Youkhana J, Raina A, Schulstad G, Croft K, Mawson A, et al.
Neoplasia
. 2025 Feb;
61:101138.
PMID: 39938155
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of just 13 %. Conventional therapies fail due to acquired chemoresistance. We previously identified MutY-Homolog (MYH), a protein that repairs...
2.
Logan A, Howard C, Huda P, Kimpton K, Ma Z, Thurecht K, et al.
J Control Release
. 2024 Feb;
367:806-820.
PMID: 38341177
High-risk neuroblastoma has poor survival due to treatment failure and off-target side effects of therapy. Small molecule inhibitors have shown therapeutic efficacy at targeting oncogenic cell cycle dysregulators, such as...
3.
Brayford S, Duly A, Teo W, Dwarte T, Gonzales-Aloy E, Ma Z, et al.
Cancer Med
. 2022 Aug;
12(4):4455-4471.
PMID: 35946957
Non-Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells...
4.
Leiske M, Mazrad Z, Zelcak A, Wahi K, Davis T, McCarroll J, et al.
Biomacromolecules
. 2022 May;
23(6):2374-2387.
PMID: 35508075
The synthesis of new amino acid-containing, cell-specific, therapeutically active polymers is presented. Amino acids served as starting material for the preparation of tailored polymers with different amino acids in the...
5.
Parker A, Teo W, Brayford S, Moorthi U, Arumugam S, Ferguson C, et al.
Cells
. 2022 Mar;
11(5).
PMID: 35269398
βIII-tubulin is a neuronal microtubule protein that is aberrantly expressed in epithelial cancers. The microtubule network is implicated in regulating the architecture and dynamics of the mitochondrial network, although the...
6.
Janjua T, Ahmed-Cox A, Meka A, Mansfeld F, Forgham H, Ignacio R, et al.
Nanoscale
. 2021 Sep;
13(40):16909-16922.
PMID: 34533167
The blood brain barrier (BBB) and blood tumour barrier (BTB) remain a major roadblock for delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is notoriously difficult to...
7.
Kokkinos J, Jensen A, Sharbeen G, McCarroll J, Goldstein D, Haghighi K, et al.
Cancers (Basel)
. 2021 Jun;
13(10).
PMID: 34067833
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and no significant improvement in patient survival has been seen in the past three decades. Treatment options are limited...
8.
Sharbeen G, McCarroll J, Akerman A, Kopecky C, Youkhana J, Kokkinos J, et al.
Cancer Res
. 2021 May;
81(13):3461-3479.
PMID: 33980655
Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation of fibrosis, the latter of which creates a physical barrier to drugs....
9.
Kokkinos J, Sharbeen G, Haghighi K, Ignacio R, Kopecky C, Gonzales-Aloy E, et al.
Sci Rep
. 2021 Jan;
11(1):1944.
PMID: 33479301
The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to the highly fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully recapitulate in pre-clinical models. To fast-track...
10.
Tjandra K, Forest C, Wong C, Alcantara S, Kelly H, Ju Y, et al.
Adv Healthc Mater
. 2020 May;
9(13):e2000261.
PMID: 32424998
There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non-specific clearance by phagocytes. An ellipsoidal polymersome system is developed with a unique tunable size and...