Joshiawa Paulk
Overview
Explore the profile of Joshiawa Paulk including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2770
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0
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Recent Articles
1.
Ting P, Borikar S, Kerrigan J, Thomsen N, Aghania E, Hinman A, et al.
Science
. 2024 Jul;
385(6704):91-99.
PMID: 38963839
Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) can ameliorate disease complications and has been intently...
2.
Souroullas G, Jeck W, Parker J, Simon J, Liu J, Paulk J, et al.
Nat Med
. 2024 Feb;
30(6):1784.
PMID: 38383796
No abstract available.
3.
4.
Remillard D, Savage N, Kedves A, Paulk J, Chen X, Garcia F, et al.
ACS Chem Biol
. 2021 Sep;
16(11):2185-2192.
PMID: 34515462
Bromodomain-containing proteins frequently reside in multisubunit chromatin complexes with tissue or cell state-specific compositions. Recent studies have revealed tumor-specific dependencies on the BAF complex bromodomain subunit BRD9 that are a...
5.
6.
Koduri V, Duplaquet L, Lampson B, Wang A, Sabet A, Ishoey M, et al.
Sci Adv
. 2021 Feb;
7(6).
PMID: 33547076
Most intracellular proteins lack hydrophobic pockets suitable for altering their function with drug-like small molecules. Recent studies indicate that some undruggable proteins can be targeted by compounds that can degrade...
7.
Akinjiyan F, Fazal A, Hild M, Beckwith R, Ross N, Paulk J, et al.
SLAS Discov
. 2020 Jan;
25(4):350-360.
PMID: 31997692
Protein turnover is highly regulated by the posttranslational process of ubiquitination. Deregulation of the ubiquitin proteasome system (UPS) has been implicated in cancer and neurodegenerative diseases, and modulating this system...
8.
Bussiere D, Xie L, Srinivas H, Shu W, Burke A, Be C, et al.
Nat Chem Biol
. 2020 Jan;
16(3):361.
PMID: 31942047
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Bussiere D, Xie L, Srinivas H, Shu W, Burke A, Be C, et al.
Nat Chem Biol
. 2019 Dec;
16(1):15-23.
PMID: 31819272
The anticancer agent indisulam inhibits cell proliferation by causing degradation of RBM39, an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and the DCAF15 E3 ligase substrate receptor,...
10.
Zhao L, Dunne C, Clausen D, Roberts J, Paulk J, Liu H, et al.
Isr J Chem
. 2019 Feb;
57(3-4):319-330.
PMID: 30760938
The synthesis of biotinylated conjugates of synthetic analogues of the potent and selective histone deacetylase (HDAC) inhibitor largazole is reported. The thiazole moiety of the parent compound's cap group was...