Josh Tycko
Overview
Explore the profile of Josh Tycko including associated specialties, affiliations and a list of published articles.
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26
Citations
984
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Recent Articles
1.
Schwartz C, Abell N, Li A, Aradhana , Tycko J, Truong A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605325
Determining the phenotypic effects of single nucleotide variants is critical for understanding the genome and interpreting clinical sequencing results. Base editors, including diversifying base editors that create C>N mutations, are...
2.
Tycko J, Van M, Aradhana , DelRosso N, Ye H, Yao D, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39487265
Transcriptional effectors are protein domains known to activate or repress gene expression; however, a systematic understanding of which effector domains regulate transcription across genomic, cell type and DNA-binding domain (DBD)...
3.
Katz N, An C, Lee Y, Tycko J, Zhang M, Kang J, et al.
bioRxiv
. 2024 Oct;
PMID: 39416069
Gene therapy holds great therapeutic potential. Yet, controlling cargo expression in single cells is limited due to the variability of delivery methods. We implement an incoherent feedforward loop based on...
4.
Valbuena R, Nigam A, Tycko J, Suzuki P, Spees K, Aradhana , et al.
bioRxiv
. 2024 Oct;
PMID: 39386603
Regulatory proteins have evolved diverse repressor domains (RDs) to enable precise context-specific repression of transcription. However, our understanding of how sequence variation impacts the functional activity of RDs is limited....
5.
Maddineni A, Liang Z, Jambardi S, Roy S, Tycko J, Patil A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386518
CRISPR-based transcriptional activation (CRISPRa) has extensive research and clinical potential. Here, we show that commonly used CRISPRa systems can exhibit pronounced cytotoxicity. We demonstrate the toxicity of published and new...
6.
Yao D, Tycko J, Oh J, Bounds L, Gosai S, Lataniotis L, et al.
Nat Methods
. 2024 Mar;
21(4):723-734.
PMID: 38504114
The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to investigate cis-regulatory mechanisms....
7.
Bajpai V, Swigut T, Mohammed J, Naqvi S, Arreola M, Tycko J, et al.
Science
. 2023 Aug;
381(6658):eade6289.
PMID: 37561850
Skin color, one of the most diverse human traits, is determined by the quantity, type, and distribution of melanin. In this study, we leveraged the light-scattering properties of melanin to...
8.
Mukund A, Tycko J, Allen S, Robinson S, Andrews C, Sinha J, et al.
Cell Syst
. 2023 Aug;
14(9):746-763.e5.
PMID: 37543039
Despite growing knowledge of the functions of individual human transcriptional effector domains, much less is understood about how multiple effector domains within the same protein combine to regulate gene expression....
9.
Ludwig C, Thurm A, Morgens D, Yang K, Tycko J, Bassik M, et al.
Cell Syst
. 2023 Jun;
14(6):482-500.e8.
PMID: 37348463
Viruses encode transcriptional regulatory proteins critical for controlling viral and host gene expression. Given their multifunctional nature and high sequence divergence, it is unclear which viral proteins can affect transcription...
10.
Marinov G, Kim S, Bagdatli S, Higashino S, Trevino A, Tycko J, et al.
Genome Biol
. 2023 Apr;
24(1):85.
PMID: 37085898
Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they...