Joseph W Polli
Overview
Explore the profile of Joseph W Polli including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
2439
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Recent Articles
11.
Patel M, Eberl H, Wolf A, Pierre E, Polli J, Zamek-Gliszczynski M
J Pharmacol Exp Ther
. 2019 Jun;
370(2):269-277.
PMID: 31175220
Cabotegravir, a novel integrase inhibitor under development for treatment and prevention of HIV, is primarily metabolized by UDP-glucuronosyltransferase (UGT)1A1 and UGT1A9 to a direct ether glucuronide metabolite. The aim of...
12.
Polli J, McCurdy C, Wurster D, DeSilva B, Bak A, Bendayan R, et al.
AAPS J
. 2018 Nov;
21(1):2.
PMID: 30392015
No abstract available.
13.
Polli J, McCurdy C, Wurster D, DeSilva B, Bak A, Bendayan R, et al.
AAPS PharmSciTech
. 2018 Nov;
19(8):3325-3327.
PMID: 30390237
No abstract available.
14.
Nabity M, Polli J, Vaidya V, Krolewski A, Glaab W
Toxicol Pathol
. 2018 Sep;
46(8):1002-1005.
PMID: 30189777
A scientific session entitled "New Frontiers: Approaches to Understand the Mechanistic Basis of Renal Toxicity" focused on novel biomarkers to monitor kidney injury both preclinically and clinically, as well as...
15.
Kenna J, Taskar K, Battista C, Bourdet D, Brouwer K, Brouwer K, et al.
Clin Pharmacol Ther
. 2018 Aug;
104(5):916-932.
PMID: 30137645
Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may contribute to the initiation of human drug-induced liver injury (DILI). Proactive evaluation and understanding of BSEP...
16.
Evers R, Piquette-Miller M, Polli J, Russel F, Sprowl J, Tohyama K, et al.
Clin Pharmacol Ther
. 2018 May;
104(5):900-915.
PMID: 29756222
Drug transporters are critically important for the absorption, distribution, metabolism, and excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of these pathways by inhibition, induction, genetic polymorphisms, or...
17.
Patel M, Johnson M, Sychterz C, Lewis G, Watson C, Ellens H, et al.
J Pharmacol Exp Ther
. 2018 Apr;
366(1):37-45.
PMID: 29653960
Atovaquone, an antiprotozoal and antipneumocystic agent, is predominantly cleared by biliary excretion of unchanged parent drug. Atovaquone is ≥10,000-fold concentrated in human bile relative to unbound plasma. Even after correcting...
18.
Reese M, Bowers G, Humphreys J, Gould E, Ford S, Webster L, et al.
Xenobiotica
. 2015 Sep;
46(5):445-56.
PMID: 26340566
1. Cabotegravir (CAB; GSK1265744) is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. 2. ...
19.
Lee C, OConnor M, Ritchie T, Galetin A, Cook J, Ragueneau-Majlessi I, et al.
Drug Metab Dispos
. 2015 Jan;
43(4):490-509.
PMID: 25587128
Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-permeability substrate drugs and mediates biliary excretion of drugs and metabolites. Based on clinical evidence of BCRP-mediated drug-drug interactions (DDIs)...
20.
Zamek-Gliszczynski M, Chu X, Polli J, Paine M, Galetin A
Drug Metab Dispos
. 2013 Dec;
42(4):650-64.
PMID: 24346835
Recent analyses demonstrated that metabolites are unlikely to contribute significantly to clinical inhibition of cytochrome P450 (P450)-mediated drug metabolism, and that only ∼2% of this type of drug interaction could...