Joseph Verdi
Overview
Explore the profile of Joseph Verdi including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
95
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Recent Articles
1.
Rivera-Correa J, Verdi J, Sherman J, Sternberg J, Raper J, Rodriguez A
PLoS Negl Trop Dis
. 2021 Sep;
15(9):e0009814.
PMID: 34587165
Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not...
2.
Pant J, Samanovic M, Nelson M, Keceli M, Verdi J, Beverley S, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1008768.
PMID: 34559857
Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects...
3.
Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, et al.
Nat Microbiol
. 2021 Jan;
6(3):392-400.
PMID: 33462435
Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. Recent studies revealed that trypanosome strains that express the variant surface glycoprotein (VSG) VSGsur possess heightened...
4.
Schaub C, Verdi J, Lee P, Terra N, Limon G, Raper J, et al.
J Biol Chem
. 2020 Jul;
295(38):13138-13149.
PMID: 32727852
The human innate immunity factor apolipoprotein L-I (APOL1) protects against infection by several protozoan parasites, including Endocytosis and acidification of high-density lipoprotein-associated APOL1 in trypanosome endosomes leads to eventual lysis...
5.
Verdi J, Zipkin R, Hillman E, Gertsch R, Pangburn S, Thomson R, et al.
Cell Host Microbe
. 2020 May;
28(1):79-88.e4.
PMID: 32416060
Trypanosomiasis is a devastating neglected tropical disease affecting livestock and humans. Humans are susceptible to two Trypanosoma brucei subspecies but protected from other trypanosomes by circulating high-density lipoprotein (HDL) complexes...
6.
Verdi J, Schaub C, Thomson R, Raper J
Methods Mol Biol
. 2020 Mar;
2116:463-483.
PMID: 32221937
Interest in trypanosome lytic factors (TLFs) and apolipoprotein L1, the ion channel-forming protein component of TLFs, has increased tenfold since 2010. This is due to the association of African variants...
7.
Pinger J, Nesic D, Ali L, Aresta-Branco F, Lilic M, Chowdhury S, et al.
Nat Microbiol
. 2018 Jul;
3(8):932-938.
PMID: 29988048
The African trypanosome Trypanosoma brucei spp. is a paradigm for antigenic variation, the orchestrated alteration of cell surface molecules to evade host immunity. The parasite elicits robust antibody-mediated immune responses...
8.
Kacer D, McIntire C, Kirov A, Kany E, Roth J, Liaw L, et al.
J Cell Physiol
. 2011 Feb;
226(11):3064-75.
PMID: 21302306
FGF1, a widely expressed proangiogenic factor involved in tissue repair and carcinogenesis, is released from cells through a non-classical pathway independent of endoplasmic reticulum and Golgi. Although several proteins participating...
9.
Duarte M, Kolev V, Kacer D, Mouta-Bellum C, Soldi R, Graziani I, et al.
Mol Biol Cell
. 2008 Sep;
19(11):4863-74.
PMID: 18784255
Angiogenesis is controlled by several regulatory mechanisms, including the Notch and fibroblast growth factor (FGF) signaling pathways. FGF1, a prototype member of FGF family, lacks a signal peptide and is...