Joseph Rapley
Overview
Explore the profile of Joseph Rapley including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
572
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Papageorgiou A, Rapley J, Mesirov J, Tamayo P, Avruch J
PLoS One
. 2015 Mar;
10(3):e0116096.
PMID: 25790369
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line,...
2.
Oshiro N, Rapley J, Avruch J
J Biol Chem
. 2013 Dec;
289(5):2658-74.
PMID: 24337580
Activation of mammalian target of rapamycin complex 1 (mTORC1) by amino acids is mediated in part by the Rag GTPases, which bind the raptor subunit of mTORC1 in an amino...
3.
Rapley J, Oshiro N, Ortiz-Vega S, Avruch J
J Biol Chem
. 2011 Sep;
286(44):38043-38053.
PMID: 21914810
Insulin activation of mTOR complex 1 is accompanied by enhanced binding of substrates. We examined the mechanism and contribution of this enhancement to insulin activation of mTORC1 signaling in 293E...
4.
Dai N, Rapley J, Angel M, Yanik M, Blower M, Avruch J
Genes Dev
. 2011 May;
25(11):1159-72.
PMID: 21576258
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin...
5.
Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, et al.
Biochem Soc Trans
. 2009 Jan;
37(Pt 1):223-6.
PMID: 19143636
The signalling function of mTOR complex 1 is activated by Rheb-GTP, which controls the catalytic competence of the mTOR (mammalian target of rapamycin) kinase domain by an incompletely understood mechanism....
6.
Rapley J, Nicolas M, Groen A, Regue L, Bertran M, Caelles C, et al.
J Cell Sci
. 2008 Nov;
121(Pt 23):3912-21.
PMID: 19001501
Nek6 and Nercc1 (also known as Nek9) belong to the NIMA family of protein kinases. Nercc1 is activated in mitosis, whereupon it binds, phosphorylates and activates Nek6. Interference with Nek6...
7.
Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N
Am J Physiol Endocrinol Metab
. 2008 Sep;
296(4):E592-602.
PMID: 18765678
TOR complex 1 (TORC1), an oligomer of the mTOR (mammalian target of rapamycin) protein kinase, its substrate binding subunit raptor, and the polypeptide Lst8/GbetaL, controls cell growth in all eukaryotes...
8.
Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, et al.
Mol Cell Biol
. 2006 Jul;
26(14):5497-508.
PMID: 16809782
CARMA1 is a central regulator of NF-kappaB activation in lymphocytes. CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor (TCR). Computational analysis of expression neighborhoods...
9.
Rapley J, Baxter J, Blot J, Wattam S, Casenghi M, Meraldi P, et al.
Mol Cell Biol
. 2005 Feb;
25(4):1309-24.
PMID: 15684383
Mitotic entry requires a major reorganization of the microtubule cytoskeleton. Nlp, a centrosomal protein that binds gamma-tubulin, is a G(2)/M target of the Plk1 protein kinase. Here, we show that...