Joseph R Inigo
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Explore the profile of Joseph R Inigo including associated specialties, affiliations and a list of published articles.
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11
Citations
205
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Recent Articles
1.
Woytash J, Kumar R, Chaudhary A, Donnelly C, Wojtulski A, Bethu M, et al.
Oncogene
. 2024 Dec;
PMID: 39690273
The mitochondrial unfolded protein response (UPR) maintains mitochondrial quality control and proteostasis under stress conditions. However, the role of UPR in aggressive and resistant prostate cancer is not clearly defined....
2.
Inigo J, Chandra D
J Hematol Oncol
. 2022 Jul;
15(1):98.
PMID: 35864539
Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations...
3.
Kumar R, Chaudhary A, Woytash J, Inigo J, Gokhale A, Bshara W, et al.
J Clin Invest
. 2022 Jun;
132(13).
PMID: 35653190
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by...
4.
Li J, Lama R, Galster S, Inigo J, Wu J, Chandra D, et al.
Mol Cancer Ther
. 2022 Feb;
21(4):535-545.
PMID: 35131878
High frequency of KRAS and TP53 mutations is a unique genetic feature of pancreatic ductal adenocarcinoma (PDAC). TP53 mutation not only renders PDAC resistance to chemotherapies but also drives PDAC...
5.
Woytash J, Inigo J, Chandra D
Methods Mol Biol
. 2022 Jan;
2413:55-62.
PMID: 35044654
Mitochondrial metabolism plays key roles in pathologies such as cancer. The five complexes of the oxidative phosphorylation (OXPHOS) system are crucial for producing ATP and maintaining cellular functions and are...
6.
Inigo J, Kumar R, Chandra D
Trends Cancer
. 2021 Sep;
7(12):1050-1053.
PMID: 34580036
Increasing evidence indicates that a mitochondria-specific stress response referred to as the 'mitochondrial unfolded protein response' (UPR) is activated to maintain mitochondrial integrity and support tumor growth. In this forum...
7.
Kumar S, OMalley J, Chaudhary A, Inigo J, Yadav N, Kumar R, et al.
Br J Cancer
. 2019 Nov;
121(11):934-943.
PMID: 31673102
Background: Interleukin-8 (IL-8) and heat shock protein 60 (Hsp60) play crucial roles in cell survival and maintenance of cellular homoeostasis. However, cross talks between these two proteins are not defined....
8.
Kumar S, Inigo J, Kumar R, Chaudhary A, OMalley J, Balachandar S, et al.
Cancer Lett
. 2017 Nov;
413:82-93.
PMID: 29107110
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for...
9.
Bhat T, Chaudhary A, Kumar S, OMalley J, Inigo J, Kumar R, et al.
Biochim Biophys Acta Rev Cancer
. 2016 Dec;
1867(1):58-66.
PMID: 27988298
Abrogation of endoplasmic reticulum (ER) protein folding triggered by exogenous or endogenous factors, stimulates a cellular stress response, termed ER stress. ER stress re-establishes ER homeostasis through integrated signaling termed...
10.
Chaudhary A, OMalley J, Kumar S, Inigo J, Kumar R, Yadav N, et al.
Front Biosci (Schol Ed)
. 2016 Nov;
9(1):154-164.
PMID: 27814581
The gap between prostate cancer disparities among American men is narrowing, which is mostly due to increased screening of African American (AA) men. However, the biological reasons for prostate cancer...