Joseph Polex-Wolf
Overview
Explore the profile of Joseph Polex-Wolf including associated specialties, affiliations and a list of published articles.
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12
Citations
737
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Recent Articles
1.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
639(8054):E17.
PMID: 40000749
No abstract available.
2.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
PMID: 39910307
The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions. However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged...
3.
Polex-Wolf J, Deibler K, Hogendorf W, Bau S, Glendorf T, Stidsen C, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadk4908.
PMID: 39630884
Glucagon-like peptide-1 (GLP-1) and leptin signal recent feeding and long-term energy stores, respectively, and play complementary roles in the modulation of energy balance. Previous work using single-cell techniques in mice...
4.
Bozadjieva-Kramer N, Shin J, Blok N, Jain C, Das N, Polex-Wolf J, et al.
Endocrinology
. 2024 Jul;
165(9).
PMID: 39045670
Classic hereditary hemochromatosis (HH) is an autosomal recessive iron-overload disorder resulting from loss-of-function mutations of the HFE gene. Patients with HH exhibit excessive hepatic iron accumulation that predisposes these patients...
5.
Rupp A, Tomlinson A, Affinati A, Yacawych W, Duensing A, True C, et al.
J Clin Invest
. 2023 Aug;
133(19).
PMID: 37581939
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the...
6.
Dowsett G, Lam B, Tadross J, Cimino I, Rimmington D, Coll A, et al.
Mol Metab
. 2021 May;
53:101240.
PMID: 33962048
Objective: The area postrema (AP) and nucleus tractus solitarius (NTS) located in the hindbrain are key nuclei that sense and integrate peripheral nutritional signals and consequently regulate feeding behaviour. While...
7.
Gabery S, Salinas C, Paulsen S, Ahnfelt-Ronne J, Alanentalo T, Baquero A, et al.
JCI Insight
. 2020 Mar;
5(6).
PMID: 32213703
Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through...
8.
Adriaenssens A, Biggs E, Darwish T, Tadross J, Sukthankar T, Girish M, et al.
Cell Metab
. 2019 Aug;
30(5):987-996.e6.
PMID: 31447324
Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting weight...
9.
Rakipovski G, Rolin B, Nohr J, Klewe I, Frederiksen K, Augustin R, et al.
JACC Basic Transl Sci
. 2019 Jan;
3(6):844-857.
PMID: 30623143
The glucagon-like peptide-1 receptor agonists (GLP-1RAs) liraglutide and semaglutide reduce cardiovascular risk in type 2 diabetes patients. The mode of action is suggested to occur through modified atherosclerotic progression. In...
10.
Polex-Wolf J, Lam B, Larder R, Tadross J, Rimmington D, Bosch F, et al.
J Clin Invest
. 2018 Jan;
128(3):960-969.
PMID: 29376887
Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased...