Joseph M Dybas
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Explore the profile of Joseph M Dybas including associated specialties, affiliations and a list of published articles.
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25
Citations
356
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Recent Articles
11.
Kim E, Dybas J, Kulej K, Reyes E, Price A, Akhtar L, et al.
Nat Microbiol
. 2021 Jan;
6(2):234-245.
PMID: 33432153
Intrinsic antiviral host factors confer cellular defence by limiting virus replication and are often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral gene expression could be...
12.
Herrmann C, Dybas J, Liddle J, Price A, Hayer K, Lauman R, et al.
Nat Microbiol
. 2020 Jul;
5(10):1217-1231.
PMID: 32661314
Viruses promote infection by hijacking the ubiquitin machinery of the host to counteract or redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that together co-opt a cellular...
13.
Field N, Elbulok O, Dybas J, Moser E, Dar A, Spruce L, et al.
Eur J Immunol
. 2020 May;
50(10):1468-1483.
PMID: 32459862
To mount an antipathogen response, CD4 T cells must undergo rapid cell proliferation; however, poorly controlled expansion can result in diseases such as autoimmunity. One important regulator of T-cell activity...
14.
Rodriguez M, Dybas J, Hughes J, Weitzman M, Boutell C
Virus Res
. 2020 May;
285:198015.
PMID: 32416261
Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the cellular proteome to create an environment permissive for virus replication. HSV-1 encodes its own RING-finger E3 ubiquitin (Ub) ligase,...
15.
Field N, OLeary C, Dybas J, Ding H, Oliver P
Methods Mol Biol
. 2020 Jan;
2111:239-256.
PMID: 31933212
Ubiquitination is a crucial component of many immune processes. While ubiquitin-mediated degradation is essential to T cell activation via T cell receptor signaling, the specific E3 ligases and substrates involved...
16.
Moser E, Roof J, Dybas J, Spruce L, Seeholzer S, Cancro M, et al.
J Exp Med
. 2019 Jul;
216(9):2170-2183.
PMID: 31311822
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show...
17.
Dybas J, OLeary C, Ding H, Spruce L, Seeholzer S, Oliver P
Nat Immunol
. 2019 May;
20(6):747-755.
PMID: 31061531
Despite gathering evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylation in T cells have focused on degradation. Here, we integrated proteomic and transcriptomic datasets from primary mouse...
18.
Dybas J, Herrmann C, Weitzman M
Curr Opin Virol
. 2018 Sep;
32:40-47.
PMID: 30261451
Viruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral manipulation of ubiquitination is the DNA damage response (DDR),...
19.
Layman A, Deng G, OLeary C, Tadros S, Thomas R, Dybas J, et al.
Nat Commun
. 2017 Jun;
8:15677.
PMID: 28580955
Foxp3 T regulatory (T) cells suppress immune cell activation and establish normal immune homeostasis. How T cells maintain their identity is not completely understood. Here we show that Ndfip1, a...
20.
Dybas J, Fiser A
Proteins
. 2016 Sep;
84(12):1859-1874.
PMID: 27671894
Structure conservation, functional similarities, and homologous relationships that exist across diverse protein topologies suggest that some regions of the protein fold universe are continuous. However, the current structure classification systems...