Joseph M Bateman
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Explore the profile of Joseph M Bateman including associated specialties, affiliations and a list of published articles.
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37
Citations
498
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Recent Articles
1.
Nixon I, Bateman J, Michaelides I, Fairley G, Pemberton M, Braybrooke E, et al.
J Org Chem
. 2024 Dec;
89(24):18301-18312.
PMID: 39656514
The increasing popularity of the dihydrouracil motif in cereblon (CRBN) recruiting proteolysis-targeting chimeras (PROTACs) has necessitated the development of a facile, cost-effective, and high-yielding method for its introduction into molecules....
2.
Shah K, He S, Turner D, Corbo J, Rebbani K, Dominguez D, et al.
Nat Commun
. 2024 Apr;
15(1):3159.
PMID: 38605040
How RNA-binding proteins (RBPs) convey regulatory instructions to the core effectors of RNA processing is unclear. Here, we document the existence and functions of a multivalent RBP-effector interface. We show...
3.
Granat L, Knorr D, Ranson D, Chakrabarty R, Chandel N, Bateman J
Biol Open
. 2024 Feb;
13(2).
PMID: 38304969
Mutations in genes that affect mitochondrial function cause primary mitochondrial diseases. Mitochondrial diseases are highly heterogeneous and even patients with the same mitochondrial disease can exhibit broad phenotypic heterogeneity, which...
4.
Shah K, He S, Turner D, Corbo J, Rebbani K, Bateman J, et al.
bioRxiv
. 2023 Oct;
PMID: 37790431
RNA-binding proteins (RBPs) are key regulators of gene expression, but how RBPs convey regulatory instructions to the core effectors of RNA processing is unclear. Here we document the existence and...
5.
Granat L, Knorr D, Ranson D, Hamer E, Chakrabarty R, Mattedi F, et al.
PLoS Genet
. 2023 Jul;
19(7):e1010793.
PMID: 37399212
Mutations in subunits of the mitochondrial NADH dehydrogenase cause mitochondrial complex I deficiency, a group of severe neurological diseases that can result in death in infancy. The pathogenesis of complex...
6.
Afratis K, Bateman J, Rahemtulla B, Hughes O, Milgram B, Mulhern T, et al.
Org Lett
. 2023 Jan;
25(3):461-465.
PMID: 36638117
The synthesis of fully substituted fused pyrroles through a multicomponent reaction between a thioamide, an aldehyde, and ammonium acetate is described. This process improves on a route commonly employed in...
7.
Baskaran P, Mihaylov S, Vinsland E, Shah K, Granat L, Ultanir S, et al.
J Biol Chem
. 2022 Dec;
299(1):102788.
PMID: 36509146
Mechanistic target of rapamycin (mTOR) is a protein kinase that integrates multiple inputs to regulate anabolic cellular processes. For example, mTOR complex 1 (mTORC1) has key functions in growth control,...
8.
Aiken S, Bateman J, Liao H, Fawcett A, Bootwicha T, Vincetti P, et al.
Nat Chem
. 2022 Nov;
15(2):248-256.
PMID: 36424454
Polyketide natural products often contain common repeat motifs, for example, propionate, acetate and deoxypropionate, and so can be synthesized by iterative processes. We report here a highly efficient iterative strategy...
9.
Girodengo M, Ultanir S, Bateman J
Front Mol Neurosci
. 2022 Oct;
15:1005631.
PMID: 36226315
Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates fundamental cellular processes including growth control, autophagy and metabolism. mTOR has key functions in nervous system development...
10.
Fiorito D, Keskin S, Bateman J, George M, Noble A, Aggarwal V
J Am Chem Soc
. 2022 May;
144(18):7995-8001.
PMID: 35499478
Bastimolide B is a polyhydroxy macrolide isolated from marine cyanobacteria displaying antimalarial activity. It features a dense array of hydroxylated stereogenic centers with 1,5-relationships along a hydrocarbon chain. These 1,5-polyols...