Joseph E Chambers
Overview
Explore the profile of Joseph E Chambers including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
1158
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Brzozowska N, Wu L, Khodzhaeva V, Griffiths W, Duckworth A, Jung H, et al.
Nat Genet
. 2025 Mar;
PMID: 40065168
Somatic variants accumulate in non-malignant tissues with age. Functional variants, leading to clonal advantage of hepatocytes, accumulate in the liver of patients with acquired chronic liver disease (CLD). Whether somatic...
2.
Baird H, Shun-Shion A, Mendes de Oliveira E, Stalder D, Liang L, Eden J, et al.
J Biol Chem
. 2024 Jul;
300(8):107562.
PMID: 39002670
The hormone leptin, primarily secreted by adipocytes, plays a crucial role in regulating whole-body energy homeostasis. Homozygous loss-of-function mutations in the leptin gene (LEP) cause hyperphagia and severe obesity, primarily...
3.
Konno T, Parutto P, Crapart C, Davi V, Bailey D, Awadelkareem M, et al.
Cell Rep
. 2024 Jul;
43(7):114357.
PMID: 38955182
Cell functions rely on intracellular transport systems distributing bioactive molecules with high spatiotemporal accuracy. The endoplasmic reticulum (ER) tubular network constitutes a system for delivering luminal solutes, including Ca, across...
4.
Liu X, Obacz J, Emanuelli G, Chambers J, Abreu S, Chen X, et al.
Chem Mater
. 2024 Apr;
36(8):3588-3603.
PMID: 38681089
The development of nanoparticle (NP)-based drug carriers has presented an exciting opportunity to address challenges in oncology. Among the 100,000 available possibilities, zirconium-based metal-organic frameworks (MOFs) have emerged as promising...
5.
Watson J, Seinkmane E, Styles C, Mihut A, Kruger L, McNally K, et al.
Nature
. 2024 Apr;
628(8009):E4.
PMID: 38589575
No abstract available.
6.
Watson J, Seinkmane E, Styles C, Mihut A, Kruger L, McNally K, et al.
Nature
. 2023 Oct;
623(7988):842-852.
PMID: 37853127
Optimum protein function and biochemical activity critically depends on water availability because solvent thermodynamics drive protein folding and macromolecular interactions. Reciprocally, macromolecules restrict the movement of 'structured' water molecules within...
7.
Watson J, Kruger L, Ben-Sasson A, Bittleston A, Shahbazi M, Planelles-Herrero V, et al.
Cell
. 2023 Sep;
186(21):4710-4727.e35.
PMID: 37774705
Polarized cells rely on a polarized cytoskeleton to function. Yet, how cortical polarity cues induce cytoskeleton polarization remains elusive. Here, we capitalized on recently established designed 2D protein arrays to...
8.
Nixon-Abell J, Ruggeri F, Qamar S, Herling T, Czekalska M, Shen Y, et al.
bioRxiv
. 2023 Mar;
PMID: 36993242
Graphical Abstract:
9.
Bravo-Perez C, Toderici M, Chambers J, Martinez-Menarguez J, Garrido-Rodriguez P, Perez-Sanchez H, et al.
JCI Insight
. 2022 Oct;
7(19).
PMID: 36214221
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical...
10.
Chambers J, Zubkov N, Kubankova M, Nixon-Abell J, Mela I, Abreu S, et al.
Sci Adv
. 2022 Apr;
8(14):eabm2094.
PMID: 35394846
Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human diseases. In α-antitrypsin deficiency, the pathogenic Z variant aberrantly assembles into polymers in the hepatocyte ER, leading...