Jennifer A Dickens
Overview
Explore the profile of Jennifer A Dickens including associated specialties, affiliations and a list of published articles.
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19
Citations
340
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Recent Articles
1.
Lim K, Rutherford E, Delpiano L, He P, Lin W, Sun D, et al.
EMBO J
. 2025 Jan;
44(3):639-664.
PMID: 39815007
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in which...
2.
Lim K, Rutherford E, Sun D, Van den Boomen D, Edgar J, Bang J, et al.
bioRxiv
. 2023 Sep;
PMID: 37693487
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases including interstitial lung disease (ILD), in which...
3.
Chambers J, Zubkov N, Kubankova M, Nixon-Abell J, Mela I, Abreu S, et al.
Sci Adv
. 2022 Apr;
8(14):eabm2094.
PMID: 35394846
Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human diseases. In α-antitrypsin deficiency, the pathogenic Z variant aberrantly assembles into polymers in the hepatocyte ER, leading...
4.
Durgia H, Nicholas A, Schoenmakers E, Dickens J, Halanaik D, Sahoo J, et al.
Thyroid
. 2021 Nov;
32(2):215-218.
PMID: 34806438
The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis. Biallelic loss-of-function mutations...
5.
Dickens J, Rutherford E, Abreu S, Chambers J, Ellis M, van Schadewijk A, et al.
Eur Respir J
. 2021 May;
59(1).
PMID: 34049951
Background: Alveolar epithelial cell dysfunction plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but remains incompletely understood. Some monogenic forms of pulmonary fibrosis are associated with...
6.
Chambers J, Dickens J, Marciniak S
Biol Cell
. 2018 Aug;
110(11):249-255.
PMID: 30129166
An important function of the endoplasmic reticulum (ER) is to serve as a site of secretory protein folding. When the accumulation of misfolded proteins threatens to disturb luminal homoeostasis, the...
7.
Malzer E, Dominicus C, Chambers J, Dickens J, Mookerjee S, Marciniak S
BMC Biol
. 2018 Apr;
16(1):34.
PMID: 29609607
Background: Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and developmental...
8.
Dickens J, Malzer E, Chambers J, Marciniak S
FEBS J
. 2018 Jan;
286(2):322-341.
PMID: 29323786
Protein misfolding within the endoplasmic reticulum (ER stress) can be a cause or consequence of pulmonary disease. Mutation of proteins restricted to the alveolar type II pneumocyte can lead to...
9.
Dickens J, Ordonez A, Chambers J, Beckett A, Patel V, Malzer E, et al.
FASEB J
. 2016 Sep;
30(12):4083-4097.
PMID: 27601439
α-Antitrypsin is a serine protease inhibitor produced in the liver that is responsible for the regulation of pulmonary inflammation. The commonest pathogenic gene mutation yields Z-α-antitrypsin, which has a propensity...
10.
Marciniak S, Ordonez A, Dickens J, Chambers J, Patel V, Dominicus C, et al.
Ann Am Thorac Soc
. 2016 Aug;
13 Suppl 4:S289-96.
PMID: 27564663
Alpha-1 antitrypsin deficiency is predominantly caused by point mutations that alter the protein's folding. These mutations fall into two broad categories: those that destabilize the protein dramatically and lead to...