Joseph D Mancias
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Explore the profile of Joseph D Mancias including associated specialties, affiliations and a list of published articles.
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72
Citations
8867
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Recent Articles
1.
Herhaus L, Gestal-Mato U, Eapen V, Macinkovic I, Bailey H, Prieto-Garcia C, et al.
Cell
. 2024 Oct;
187(25):7285-7302.e29.
PMID: 39481378
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here, we show that the immunity-related GTPase family Q protein (IRGQ),...
2.
Fisher A, Phillips S, Wang C, Paulo J, Xiao X, Xu Y, et al.
Blood
. 2024 Oct;
145(6):625-634.
PMID: 39437541
The liver hormone hepcidin regulates systemic iron homeostasis to provide enough iron for vital processes while limiting toxicity. Hepcidin acts by degrading its receptor ferroportin (encoded by Slc40a1) to decrease...
3.
Segura-Roman A, Citron Y, Shin M, Sindoni N, Maya-Romero A, Rapp S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211170
Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα/β) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). PKA engages in poorly understood interactions...
4.
Nguyen T, Mancias J
Methods Mol Biol
. 2024 Aug;
2845:177-189.
PMID: 39115666
Ferritinophagy is a selective form of autophagy in which ferritin, the primary intracellular iron storage protein complex, is targeted by NCOA4 (Nuclear receptor coactivator 4) to the lysosome for degradation....
5.
Dilly J, Hoffman M, Abbassi L, Li Z, Paradiso F, Parent B, et al.
Cancer Discov
. 2024 Jul;
14(11):2135-2161.
PMID: 38975874
KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and...
6.
Hoelzgen F, Nguyen T, Klukin E, Boumaiza M, Srivastava A, Kim E, et al.
Nat Commun
. 2024 May;
15(1):3802.
PMID: 38714719
The interaction between nuclear receptor coactivator 4 (NCOA4) and the iron storage protein ferritin is a crucial component of cellular iron homeostasis. The binding of NCOA4 to the FTH1 subunits...
7.
DeAngelo S, Zhao L, Dziechciarz S, Shin M, Solanki S, Balia A, et al.
bioRxiv
. 2024 Apr;
PMID: 38617233
Ferroptosis is a non-apoptotic form of cell death resulting from the iron-dependent accumulation of lipid peroxides. Colorectal cancer (CRC) cells accumulate high levels of intracellular iron and reactive oxygen species...
8.
Fisher A, Phillips S, Wang C, Paulo J, Xiao X, Moschetta G, et al.
Blood
. 2024 Mar;
143(23):2433-2437.
PMID: 38518102
Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor...
9.
Chen B, Stark D, Jadhav P, Lynn-Nguyen T, Halligan B, Rossiter N, et al.
bioRxiv
. 2024 Feb;
PMID: 38352460
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding...
10.
Chuong M, Lee P, Low D, Kim J, Mittauer K, Bassetti M, et al.
Radiother Oncol
. 2023 Dec;
191():110064.
PMID: 38135187
Background And Purpose: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of...