Joseph C Besharse
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Explore the profile of Joseph C Besharse including associated specialties, affiliations and a list of published articles.
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36
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1470
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Recent Articles
11.
Miesfeld J, Gestri G, Clark B, Flinn M, Poole R, Bader J, et al.
Development
. 2015 Jul;
142(17):3021-32.
PMID: 26209646
The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis. Several transcription factors and signaling...
12.
Fogerty J, Besharse J
Adv Exp Med Biol
. 2014 Mar;
801:355-63.
PMID: 24664718
We have characterized a naturally-occurring mutation in mice that causes slow, progressive photoreceptor degeneration, white fundus flecks, and late-onset RPE atrophy. These animals predictably lose visual function as photoreceptors degenerate....
13.
Wong-Riley M, Besharse J
Biomol Concepts
. 2013 Jun;
3(3):267-282.
PMID: 23762210
Kinesins are ATP-dependent molecular motors that carry cargos along microtubules, generally in an anterograde direction. They are classified into 14 distinct families with varying structural and functional characteristics. KIF17 is...
14.
Malicki J, Besharse J
Vision Res
. 2012 Nov;
75:33-6.
PMID: 23123805
This review focuses on recent advances in the understanding of kinesin-2 family motors in vertebrate photoreceptor development. Zebrafish photoreceptors develop by the 3rd day of embryogenesis, making it possible to...
15.
Bader J, Kusik B, Besharse J
Vision Res
. 2012 Oct;
75:37-43.
PMID: 23099049
Multiple proteins are targeted to photoreceptor outer segments (OSs) where they function in phototransduction. Intraflagellar transport (IFT), a highly conserved bidirectional transport pathway occurring along the microtubules of the ciliary...
16.
Scoma H, Humby M, Yadav G, Zhang Q, Fogerty J, Besharse J
PLoS One
. 2011 Oct;
6(9):e25382.
PMID: 21966515
We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates...
17.
Fogerty J, Besharse J
Invest Ophthalmol Vis Sci
. 2011 Aug;
52(10):7256-66.
PMID: 21810984
Purpose: The authors have identified a recessive mutation causing progressive retinal degeneration, white fundus flecks, and eventual retinal pigment epithelium (RPE) atrophy. The goal of these studies was to characterize...
18.
Insinna C, Baye L, Amsterdam A, Besharse J, Link B
Neural Dev
. 2010 Apr;
5:12.
PMID: 20412557
Background: Photoreceptors of the retina are highly compartmentalized cells that function as the primary sensory neurons for receiving and initiating transmission of visual information. Proper morphogenesis of photoreceptor neurons is...
19.
Insinna C, Luby-Phelps K, Link B, Besharse J
Methods Cell Biol
. 2010 Apr;
93:219-34.
PMID: 20409820
The photoreceptor outer segment (OS), a well-defined sensory cilium, provides an important context for the study of intraflagellar transport (IFT). The early phases of OS development involve successive events that...
20.
Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J
Dev Dyn
. 2009 Apr;
238(9):2211-22.
PMID: 19384852
Kinesin 2 family members are involved in transport along ciliary microtubules. In Caenorhabditis elegans channel cilia, kinesin II and OSM-3 cooperate along microtubule doublets of the axoneme middle segment, whereas...