Sean R Kundinger
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Explore the profile of Sean R Kundinger including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
372
Followers
0
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Recent Articles
1.
Arakhamia T, Lee C, Carlomagno Y, Kumar M, Duong D, Wesseling H, et al.
Cell
. 2021 Dec;
184(25):6207-6210.
PMID: 34890553
No abstract available.
2.
Kundinger S, Dammer E, Yin L, Hurst C, Shapley S, Ping L, et al.
J Biol Chem
. 2021 Oct;
297(5):101306.
PMID: 34673031
Posttranslational modifications (PTMs) such as phosphorylation of RNA-binding proteins (RBPs) regulate several critical steps in RNA metabolism, including spliceosome assembly, alternative splicing, and mRNA export. Notably, serine-/arginine- (SR)-rich RBPs are...
3.
Guo Q, Dammer E, Zhou M, Kundinger S, Gearing M, Lah J, et al.
Front Mol Neurosci
. 2021 Apr;
14:623659.
PMID: 33815056
Core spliceosome and related RNA-binding proteins aggregate in Alzheimer's disease (AD) brain even in early asymptomatic stages (AsymAD) of disease. To assess the specificity of RNA-binding protein aggregation in AD,...
4.
Ping L, Kundinger S, Duong D, Yin L, Gearing M, Lah J, et al.
Sci Data
. 2020 Sep;
7(1):315.
PMID: 32985496
Alzheimer's disease (AD) is characterized by an early, asymptomatic phase (AsymAD) in which individuals exhibit amyloid-beta (Aβ) plaque accumulation in the absence of clinically detectable cognitive decline. Here we report...
5.
Arakhamia T, Lee C, Carlomagno Y, Duong D, Kundinger S, Wang K, et al.
Cell
. 2020 Feb;
180(4):633-644.e12.
PMID: 32032505
Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies. However, it is not known what controls the formation and templated seeding of strain-specific structures associated with individual...
6.
Kundinger S, Bishof I, Dammer E, Duong D, Seyfried N
J Proteome Res
. 2020 Jan;
19(4):1574-1591.
PMID: 31994892
Post-translational modifications (PTMs) within arginine (Arg)-rich RNA-binding proteins, such as phosphorylation and methylation, regulate multiple steps in RNA metabolism. However, the identification of PTMs within Arg-rich domains with complete trypsin...
7.
Lewis T, Kundinger S, Link B, Insinna C, Besharse J
BMC Cell Biol
. 2018 Nov;
19(1):25.
PMID: 30458707
Background: KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear....
8.
Bishof I, Dammer E, Duong D, Kundinger S, Gearing M, Lah J, et al.
J Biol Chem
. 2018 May;
293(28):11047-11066.
PMID: 29802200
The U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and other RNA-binding proteins (RBPs) are mislocalized to cytoplasmic neurofibrillary Tau aggregates in Alzheimer's disease (AD), yet the co-aggregation mechanisms are incompletely...
9.
Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J
Dev Biol
. 2017 Mar;
425(2):176-190.
PMID: 28341548
Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size. However, two genetic mutant lines, osm-3/kif17...