Joseph C Besharse
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Explore the profile of Joseph C Besharse including associated specialties, affiliations and a list of published articles.
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36
Citations
1470
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Recent Articles
1.
Brandt Z, Collery R, Besharse J, Link B
Invest Ophthalmol Vis Sci
. 2021 Dec;
62(15):13.
PMID: 34913948
Purpose: Proper refractive development of the eye, termed emmetropization, is critical for focused vision and is impacted by both genetic determinants and several visual environment factors. Improper emmetropization caused by...
2.
Sadler K, Lewis T, Waltz T, Besharse J, Stucky C
Pain Rep
. 2019 Oct;
4(4):e765.
PMID: 31579856
Introduction: Many patients with sickle cell disease (SCD) suffer from chronic pain, which is often described as neuropathic in nature. Although vascular and inflammatory pathology undoubtedly contribute to the SCD...
3.
Spencer W, Ding J, Lewis T, Yu C, Phan S, Pearring J, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(26):13087-13096.
PMID: 31189593
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple...
4.
Han D, Skumatz C, Besharse J, Kassem I
J Ocul Pharmacol Ther
. 2019 Mar;
35(5):278-282.
PMID: 30916605
Aflibercept (Eylea™, Regeneron) is supplied in single-use glass vials along with 1 cc polycarbonate syringes. We sought to determine if storage of aflibercept for sustained periods within these syringes would...
5.
Lewis T, Kundinger S, Link B, Insinna C, Besharse J
BMC Cell Biol
. 2018 Nov;
19(1):25.
PMID: 30458707
Background: KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear....
6.
Besharse J, Brandon R
J Morphol
. 2018 Oct;
144(4):381-405.
PMID: 30322217
Comparative histological observations of the eyes of Typhlotriton spelaeus and several epigean, plethodontid species indicate that the principal postembryonic degenerative changes in the eyes of T. spelaeus involve the eyelids...
7.
Lewis T, Zareba M, Link B, Besharse J
Mol Biol Cell
. 2017 Nov;
29(2):180-190.
PMID: 29142075
Teleosts and amphibians exhibit retinomotor movements, morphological changes in photoreceptors regulated by light and circadian rhythms. Cone myoid elongation occurs during dark adaptation, leading to the positioning of the cone...
8.
Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J
Dev Biol
. 2017 Mar;
425(2):176-190.
PMID: 28341548
Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size. However, two genetic mutant lines, osm-3/kif17...
9.
Collery R, Volberding P, Bostrom J, Link B, Besharse J
Invest Ophthalmol Vis Sci
. 2016 Dec;
57(15):6805-6814.
PMID: 28002843
Purpose: Mutations in membrane frizzled-related protein (MFRP) are associated with nanophthalmia, hyperopia, foveoschisis, irregular patches of RPE atrophy, and optic disc drusen in humans. Mouse mfrp mutants show retinal degeneration...
10.
Besharse J, McMahon D
J Biol Rhythms
. 2016 Apr;
31(3):223-43.
PMID: 27095816
Ocular clocks, first identified in the retina, are also found in the retinal pigment epithelium (RPE), cornea, and ciliary body. The retina is a complex tissue of many cell types...