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Joseph A McQuail

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Articles 24
Citations 538
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Recent Articles
1.
Horovitz D, Askins L, Regnier G, McQuail J
Neurobiol Aging . 2025 Feb; 148:80-97. PMID: 39954409
Age-related cognitive decline varies widely among individuals, with some showing resilience despite older age. This study examines synaptic markers of glutamatergic and GABAergic neurotransmission in the hippocampus and cortex of...
2.
Waigi E, Pernomian L, Crockett A, Costa T, Townsend Jr P, Webb R, et al.
Geroscience . 2024 Jun; 46(6):5517-5536. PMID: 38862757
Increasing evidence shows that cardiovascular diseases (CVDs) are associated with an increased risk of cognitive impairment and Alzheimer's diseases (AD). It is unknown whether systemic vascular dysfunction occurs prior to...
3.
Braunstein P, Horovitz D, Hampton A, Hollis F, Newman L, Enos R, et al.
Aging Brain . 2024 Apr; 5:100116. PMID: 38596458
Defective brain glucose utilization is a hallmark of Alzheimer's disease (AD) while Type II diabetes and elevated blood glucose escalate the risk for AD in later life. Isolating contributions of...
4.
Gandy H, Hollis F, Hernandez C, McQuail J
Front Aging Neurosci . 2024 Jan; 15:1306496. PMID: 38259638
The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan and contribute to impairment of neural function and cognition in advanced aging....
5.
Hernandez C, McQuail J, Ten Eyck T, Wheeler A, Labiste C, Setlow B, et al.
Neuropharmacology . 2022 Feb; 209:109001. PMID: 35189132
The ability to decide adaptively between immediate vs. delayed gratification (intertemporal choice) is critical for well-being and is associated with a range of factors that influence quality of life. In...
6.
McQuail J, Beas B, Kelly K, Hernandez 3rd C, Bizon J, Frazier C
Neuropharmacology . 2021 Jul; 197:108720. PMID: 34273386
Ionotropic glutamate receptors of the NMDA and AMPA subtypes transduce excitatory signaling on neurons in the prefrontal cortex (PFC) in support of cognitive flexibility. Cognitive flexibility is reliably observed to...
7.
McQuail J, Dunn A, Stern Y, Barnes C, Kempermann G, Rapp P, et al.
Front Aging Neurosci . 2021 Feb; 12:607685. PMID: 33551788
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and...
8.
Hernandez A, Hernandez C, Truckenbrod L, Campos K, McQuail J, Bizon J, et al.
Front Aging Neurosci . 2019 Oct; 11:239. PMID: 31607897
As the number of individuals living beyond the age of 65 is rapidly increasing, so is the need to develop strategies to combat the age-related cognitive decline that may threaten...
9.
Hernandez A, Hernandez C, Campos K, Truckenbrod L, Federico Q, Moon B, et al.
Front Aging Neurosci . 2018 Dec; 10:391. PMID: 30559660
Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the...
10.
McQuail J, Krause E, Setlow B, Scheuer D, Bizon J
Neurobiol Aging . 2018 Aug; 71:156-160. PMID: 30144648
A substantial literature details the relationship between age-related changes to the hypothalamic-pituitary-adrenal axis and deterioration of mnemonic functions that depend on the hippocampus. The relationship between adrenocortical status and other...