Joseph A DiDonato
Overview
Explore the profile of Joseph A DiDonato including associated specialties, affiliations and a list of published articles.
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Articles
85
Citations
10873
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Recent Articles
1.
Tang W, DiDonato J, Allayee H, Hazen S
Nat Med
. 2024 Sep;
30(9):2448-2449.
PMID: 39237627
No abstract available.
2.
Tang W, Lemaitre R, Jensen P, Wang M, Wang Z, Li X, et al.
Circ Heart Fail
. 2024 Aug;
17(8):e011569.
PMID: 39119698
Background: Growing evidence indicates that trimethylamine -oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk. It remains unclear how circulating...
3.
Saha P, Gogonea V, Sweet W, Mohan M, Singh K, Anderson J, et al.
Nat Commun
. 2024 Aug;
15(1):6696.
PMID: 39107277
Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically...
4.
Verhaar B, Wijdeveld M, Wortelboer K, Rampanelli E, Levels J, Collard D, et al.
Hypertension
. 2024 Jul;
81(10):2124-2136.
PMID: 39034917
Background: The microbiota-derived short chain fatty acid butyrate has been shown to lower blood pressure (BP) in rodent studies. Nonetheless, the net effect of butyrate on hypertension in humans remains...
5.
Wang M, Tang W, Li X, de Oliveira Otto M, Lee Y, Lemaitre R, et al.
J Am Soc Nephrol
. 2024 Apr;
35(6):749-760.
PMID: 38593157
No abstract available.
6.
Ferrell M, Wang Z, Anderson J, Li X, Witkowski M, DiDonato J, et al.
Nat Med
. 2024 Mar;
30(6):1791.
PMID: 38448791
No abstract available.
7.
Ferrell M, Wang Z, Anderson J, Li X, Witkowski M, DiDonato J, et al.
Nat Med
. 2024 Feb;
30(2):424-434.
PMID: 38374343
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its...
8.
Dwidar M, Buffa J, Wang Z, Santos A, Tittle A, Fu X, et al.
mBio
. 2023 Sep;
14(5):e0093723.
PMID: 37737636
The key atherosclerotic TMAO originates from the initial gut microbial conversion of -carnitine and other dietary compounds into TMA. Developing therapeutic strategies to block gut microbial TMA production needs a...
9.
Wang M, Li X, Wang Z, de Oliveira Otto M, Lemaitre R, Fretts A, et al.
Eur Heart J
. 2023 Mar;
44(18):1608-1618.
PMID: 36883587
Aims: Little is known about associations of trimethylamine N-oxide (TMAO), a novel gut microbiota-generated metabolite of dietary phosphatidylcholine and carnitine, and its changes over time with all-cause and cause-specific mortality...
10.
Zhu Y, Dwidar M, Nemet I, Buffa J, Sangwan N, Li X, et al.
Cell Host Microbe
. 2022 Dec;
31(1):18-32.e9.
PMID: 36549300
Recent studies show gut microbiota-dependent metabolism of dietary phenylalanine into phenylacetic acid (PAA) is critical in phenylacetylglutamine (PAGln) production, a metabolite linked to atherosclerotic cardiovascular disease (ASCVD). Accordingly, microbial enzymes...