Bruce S Levison
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Explore the profile of Bruce S Levison including associated specialties, affiliations and a list of published articles.
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29
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9288
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Recent Articles
1.
Wang Z, Hazen J, Jia X, Org E, Zhao Y, Osborn L, et al.
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34948275
-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects...
2.
Ferrell M, Bazeley P, Wang Z, Levison B, Li X, Jia X, et al.
J Am Heart Assoc
. 2021 Oct;
10(21):e021934.
PMID: 34713713
Background Trimethylamine--oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat....
3.
Zamanian-Daryoush M, Gogonea V, DiDonato A, Buffa J, Choucair I, Levison B, et al.
J Biol Chem
. 2020 Feb;
295(15):4836-4848.
PMID: 32098873
Apolipoprotein A-I (apoA-I) is the major protein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation in the artery wall. In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications...
4.
Li X, Obeid S, Wang Z, Hazen B, Li L, Wu Y, et al.
Eur Heart J
. 2019 May;
40(32):2700-2709.
PMID: 31049589
Aims: Trimethyllysine (TML) serves as a nutrient precursor of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and is associated with incident cardiovascular (CV) events in stable subjects. We examined the...
5.
Wang Z, Bergeron N, Levison B, Li X, Chiu S, Jia X, et al.
Eur Heart J
. 2018 Dec;
40(7):583-594.
PMID: 30535398
Aims: Carnitine and choline are major nutrient precursors for gut microbiota-dependent generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed randomized-controlled dietary intervention studies to explore the impact of...
6.
Koeth R, Lam-Galvez B, Kirsop J, Wang Z, Levison B, Gu X, et al.
J Clin Invest
. 2018 Dec;
129(1):373-387.
PMID: 30530985
Background: l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota-dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic...
7.
Palagama D, Baliu-Rodriguez D, Lad A, Levison B, Kennedy D, Haller S, et al.
J Chromatogr A
. 2018 Sep;
1573:66-77.
PMID: 30201162
The protocols for solid-phase extraction (SPE) of six microcystins (MCs; MC-LR, MC-RR, MC-LA, MC-LF, MC-LW, and MC-YR) from mouse urine, mouse plasma, and human serum are reported. The quantification of...
8.
Roberts A, Gu X, Buffa J, Hurd A, Wang Z, Zhu W, et al.
Nat Med
. 2018 Aug;
24(9):1407-1417.
PMID: 30082863
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks...
9.
Smits L, Kootte R, Levin E, Prodan A, Fuentes S, Zoetendal E, et al.
J Am Heart Assoc
. 2018 Mar;
7(7).
PMID: 29581220
Background: Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan...
10.
Lin H, Levison B, Buffa J, Huang Y, Fu X, Wang Z, et al.
Free Radic Biol Med
. 2017 Jan;
104:20-31.
PMID: 28069522
Recent studies reveal 2-aminoadipic acid (2-AAA) is both elevated in subjects at risk for diabetes and mechanistically linked to glucose homeostasis. Prior studies also suggest enrichment of protein-bound 2-AAA as...