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Josef Wissing

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Articles 34
Citations 847
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Recent Articles
1.
Molinari G, Ribeiro S, Muller K, Mayer B, Rohde M, Arce-Rodriguez A, et al.
Microb Biotechnol . 2025 Feb; 18(2):e70096. PMID: 39937155
The DnaK (Hsp70) protein is an essential ATP-dependent chaperone foldase and holdase found in most organisms. In this study, combining multiple experimental approaches we determined FliC as major interaction partner...
2.
Prabhakar P, Pielot R, Landgraf P, Wissing J, Bayrhammer A, van Ham M, et al.
Glia . 2022 Nov; 71(3):682-703. PMID: 36401581
Astrocytes exhibit regional heterogeneity in morphology, function and molecular composition to support and modulate neuronal function and signaling in a region-specific manner. To characterize regional heterogeneity of astrocytic proteomes of...
3.
Fuchs S, Kucklick M, Lehmann E, Beckmann A, Wilkens M, Kolte B, et al.
PLoS Genet . 2021 Jun; 17(6):e1009585. PMID: 34061833
Small proteins play essential roles in bacterial physiology and virulence, however, automated algorithms for genome annotation are often not yet able to accurately predict the corresponding genes. The accuracy and...
4.
Dominguez-Perez D, Almeida D, Wissing J, Machado A, Jansch L, Antunes A, et al.
Int J Mol Sci . 2021 Apr; 22(7). PMID: 33806079
We focus on the stalked goose barnacle adhesive system, an opportunistic less selective species for the substrate, found attached to a variety of floating objects at seas. Adhesion is an...
5.
Dominguez-Perez D, Almeida D, Wissing J, Machado A, Jansch L, Castro L, et al.
Int J Mol Sci . 2020 Apr; 21(7). PMID: 32260514
Adhesive secretion has a fundamental role in barnacles' survival, keeping them in an adequate position on the substrate under a variety of hydrologic regimes. It arouses special interest for industrial...
6.
Klahn P, Fetz V, Ritter A, Collisi W, Hinkelmann B, Arnold T, et al.
Chem Sci . 2019 Jun; 10(20):5197-5210. PMID: 31191875
The concept of targeted drug conjugates has been successfully translated to clinical practice in oncology. Whereas the majority of cytotoxic effectors in drug conjugates are directed against either DNA or...
7.
Unal C, Karagoz M, Berges M, Priebe C, Borrero de Acuna J, Wissing J, et al.
Front Pharmacol . 2019 Apr; 10:340. PMID: 31024308
The Gram-positive pathogen is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl--isomerases (PPIases) are well established modulators of virulence that influence the outcome of human pathologies during...
8.
Bussey K, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, et al.
PLoS Pathog . 2018 Mar; 14(3):e1006937. PMID: 29499066
Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few oncogenic human viruses known to date. Its large genome encodes more than 85 proteins and includes both unique viral proteins as...
9.
van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, et al.
Eur J Immunol . 2017 Aug; 47(12):2043-2058. PMID: 28833060
Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains...
10.
Boehme J, Stegemann-Koniszewski S, Autengruber A, Peters N, Wissing J, Jansch L, et al.
Sci Rep . 2017 Jul; 7(1):4972. PMID: 28694492
Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to...