Jose A Cisneros
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Explore the profile of Jose A Cisneros including associated specialties, affiliations and a list of published articles.
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21
Citations
242
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Recent Articles
1.
Kagiou C, Cisneros J, Farnung J, Liwocha J, Offensperger F, Dong K, et al.
Nat Commun
. 2024 Jun;
15(1):5409.
PMID: 38926334
Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600...
2.
Ng A, Offensperger F, Cisneros J, Scholes N, Malik M, Villanti L, et al.
ACS Chem Biol
. 2023 Dec;
18(12):2464-2473.
PMID: 38098458
Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiquitin-proteasome system. While MGDs were historically discovered serendipitously, approaches for MGD discovery now include cell-viability-based drug...
3.
Ippolito J, Niu H, Bertoletti N, Carter Z, Jin S, Spasov K, et al.
ACS Med Chem Lett
. 2021 Feb;
12(2):249-255.
PMID: 33603971
Covalent inhibitors of wild-type HIV-1 reverse transcriptase (CRTIs) are reported. Three compounds derived from catechol diether non-nucleoside inhibitors (NNRTIs) with addition of a fluorosulfate warhead are demonstrated to covalently modify...
4.
Kudalkar S, Ullah I, Bertoletti N, Mandl H, Cisneros J, Beloor J, et al.
Antiviral Res
. 2019 Apr;
167:110-116.
PMID: 31034849
Combination antiretroviral therapy (cART) has been proven effective in inhibiting human immunodeficiency virus type 1 (HIV-1) infection and has significantly improved the health outcomes in acquired immune deficiency syndrome (AIDS)...
5.
Kudalkar S, Beloor J, Quijano E, Spasov K, Lee W, Cisneros J, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(35):E8114-E8115.
PMID: 30097540
No abstract available.
6.
Trivedi-Parmar V, Robertson M, Cisneros J, Krimmer S, Jorgensen W
ChemMedChem
. 2018 Mar;
13(11):1092-1097.
PMID: 29575754
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as...
7.
Kudalkar S, Beloor J, Quijano E, Spasov K, Lee W, Cisneros J, et al.
Proc Natl Acad Sci U S A
. 2017 Dec;
115(4):E802-E811.
PMID: 29279368
The HIV-1 pandemic affecting over 37 million people worldwide continues, with nearly one-half of the infected population on highly active antiretroviral therapy (HAART). Major therapeutic challenges remain because of the...
8.
Dawson T, Dziedzic P, Robertson M, Cisneros J, Krimmer S, Newton A, et al.
ACS Med Chem Lett
. 2017 Dec;
8(12):1287-1291.
PMID: 29259749
Coordination of the ammonium group of Lys32 in the active site of human macrophage migration inhibitory factor (MIF) using a 1,7-naphthyridin-8-one instead of a quinoline is investigated. Both gas- and...
9.
Chan A, Lee W, Spasov K, Cisneros J, Kudalkar S, Petrova Z, et al.
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9725-9730.
PMID: 28827354
Development of resistance remains a major challenge for drugs to treat HIV-1 infections, including those targeting the essential viral polymerase, HIV-1 reverse transcriptase (RT). Resistance associated with the Tyr181Cys mutation...
10.
Newton A, Deiana L, Puleo D, Cisneros J, Cutrona K, Schlessinger J, et al.
ACS Med Chem Lett
. 2017 Jun;
8(6):614-617.
PMID: 28626520
A competitive fluorescence polarization (FP) assay is reported for determining binding affinities of probe molecules with the pseudokinase JAK2 JH2 allosteric site. The syntheses of the fluorescent and used in...