Michael J Robertson
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Explore the profile of Michael J Robertson including associated specialties, affiliations and a list of published articles.
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98
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3831
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Recent Articles
1.
Clayton J, Shi L, Robertson M, Skiniotis G, Michaelides M, Stavitskaya L, et al.
bioRxiv
. 2025 Feb;
PMID: 39990498
Nitazenes are a class of novel synthetic opioids with exceptionally high potency. Currently, an experimental structure of OR-opioid receptor (OR) in complex with a nitazene is lacking. Here we used...
2.
He F, Wu C, Gao Y, Rahman S, Zaoralova M, Papasergi-Scott M, et al.
Nature
. 2024 Feb;
626(8001):1141-1148.
PMID: 38326620
The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that has a central role in regulating systemic calcium homeostasis. Here we use cryo-electron microscopy and functional assays to...
3.
Robertson M, Zingas N, Benzel C, OHara N, OToole R, Hempen E
Injury
. 2023 Sep;
54(10):111004.
PMID: 37666043
Objectives: To determine the proportion of patients who fail manipulation under anesthesia (MUA) as a treatment for posttraumatic knee stiffness and determine the risk factors for MUA failure. Methods: A...
4.
Vizurraga A, Robertson M, Yu M, Skiniotis G, Tall G
Mol Pharmacol
. 2023 Jun;
104(1):28-41.
PMID: 37290962
GPR56 is a widely expressed adhesion GPCR (AGPCR) that has pleotropic roles in brain development, platelet function, cancer, and more. Nearly all AGPCRs possess extracellular regions that bind protein ligands...
5.
Kumar K, Robertson M, Thadhani E, Wang H, Suomivuori C, Powers A, et al.
Nat Commun
. 2023 May;
14(1):2672.
PMID: 37160876
Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses. Hence, understanding the structural and functional...
6.
Atallah-Yunes S, Salman O, Robertson M
Br J Haematol
. 2023 Mar;
201(3):383-395.
PMID: 36946218
Post-transplant lymphoproliferative disorder (PTLD) is rare and heterogeneous lymphoid proliferations that occur as a result of immunosuppression following solid organ transplant (SOT) and haematopoietic stem cell transplant (HSCT) with the...
7.
Faouzi A, Wang H, Zaidi S, DiBerto J, Che T, Qu Q, et al.
Nature
. 2022 Nov;
613(7945):767-774.
PMID: 36450356
Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain management, but are considered a major public health concern owing to their adverse side effects, including lethal...
8.
Qu Q, Huang W, Aydin D, Paggi J, Seven A, Wang H, et al.
Nat Chem Biol
. 2022 Nov;
19(4):423-430.
PMID: 36411392
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the...
9.
Robertson M, Papasergi-Scott M, He F, Seven A, Meyerowitz J, Panova O, et al.
Nat Struct Mol Biol
. 2022 Nov;
29(12):1188-1195.
PMID: 36396979
Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. Despite representing one of the largest classes...
10.
Kaplan A, Confair D, Kim K, Barros-Alvarez X, Rodriguiz R, Yang Y, et al.
Nature
. 2022 Sep;
610(7932):582-591.
PMID: 36171289
There is considerable interest in screening ultralarge chemical libraries for ligand discovery, both empirically and computationally. Efforts have focused on readily synthesizable molecules, inevitably leaving many chemotypes unexplored. Here we...