Jorge Lloberas
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Explore the profile of Jorge Lloberas including associated specialties, affiliations and a list of published articles.
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1449
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Recent Articles
1.
Arpa L, Batlle C, Jiang P, Caelles C, Lloberas J, Celada A
Cells
. 2023 May;
12(8).
PMID: 37190036
IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6...
2.
Aparici-Herraiz I, Sanchez-Sanchez G, Batlle C, Rehues P, Lopez-Serrat M, Valverde-Estrella L, et al.
J Innate Immun
. 2022 Nov;
15(1):297-316.
PMID: 36380629
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1)...
3.
Vico T, Youssif C, Zare F, Comalada M, Sebastian C, Lloberas J, et al.
Cells
. 2022 Mar;
11(6).
PMID: 35326386
At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways...
4.
Tur J, Farrera C, Sanchez-Tillo E, Vico T, Guerrero-Gonzalez P, Fernandez-Elorduy A, et al.
Immunobiology
. 2021 Jul;
226(5):152114.
PMID: 34303919
The induction of major histocompatibility complex (MHC) class II proteins by interferon gamma (IFN-γ) in macrophages play an important role during immune responses. Here we explore the signaling pathways involved...
5.
Lloberas J, Munoz J, Hernandez-Alvarez M, Cardona P, Zorzano A, Celada A
Autophagy
. 2020 Nov;
16(12):2307-2309.
PMID: 33171058
MFN2 (mitofusin 2) is required for mitochondrial fusion and for mitochondria-endoplasmic reticulum interaction. Using myeloid-conditional KO mice models, we found that MFN2 but not MFN1 is a prerequisite for the...
6.
Tur J, Pereira-Lopes S, Vico T, Marin E, Munoz J, Hernandez-Alvarez M, et al.
Cell Rep
. 2020 Aug;
32(8):108079.
PMID: 32846136
Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied...
7.
Valverde-Estrella L, Lopez-Serrat M, Sanchez-Sanchez G, Vico T, Lloberas J, Celada A
Eur J Immunol
. 2020 Apr;
50(9):1321-1334.
PMID: 32270872
SAMHD1 is an enzyme with phosphohydrolase activity. Mutations in SAMHD1 have been linked to the development of Aicardi-Goutières syndrome in humans. This enzyme also has the capacity to restrict HIV...
8.
Lloberas J, Valverde-Estrella L, Tur J, Vico T, Celada A
Front Mol Biosci
. 2016 Jul;
3:28.
PMID: 27446931
Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in...
9.
Pereira-Lopes S, Tur J, Calatayud-Subias J, Lloberas J, Stracker T, Celada A
Blood
. 2015 Sep;
126(22):2502-10.
PMID: 26324700
Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response....
10.
Serrat N, Sebastian C, Pereira-Lopes S, Valverde-Estrella L, Lloberas J, Celada A
J Immunol
. 2013 Dec;
192(1):418-26.
PMID: 24307736
LPS induces the expression of NO synthase 2 (nos2) in macrophages. The expression of this molecule is one of the hallmarks of classical activation. In this paper, we describe that...