Carlos Sebastian
Overview
Explore the profile of Carlos Sebastian including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
33
Citations
2598
Followers
0
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Recent Articles
1.
Poltl L, Kitsera M, Raffl S, Schild S, Cosic A, Kienesberger S, et al.
Cell Rep
. 2023 Mar;
42(3):112199.
PMID: 36870054
The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis. Renewal of the intestinal...
2.
Sebastian C, Vong J, Mayekar M, Tummala K, Singh I
Front Genet
. 2022 Apr;
13:877538.
PMID: 35360874
No abstract available.
3.
Vico T, Youssif C, Zare F, Comalada M, Sebastian C, Lloberas J, et al.
Cells
. 2022 Mar;
11(6).
PMID: 35326386
At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways...
4.
Sebastian C, Ferrer C, Serra M, Choi J, Ducano N, Mira A, et al.
Nat Commun
. 2022 Mar;
13(1):1503.
PMID: 35314684
Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylase...
5.
Fortuny L, Sebastian C
Genes (Basel)
. 2021 Nov;
12(11).
PMID: 34828304
Beyond its role on the conversion of nutrients into energy and biomass, cellular metabolism is actively involved in the control of many physiological processes. Among these, it is becoming increasingly...
6.
Choi J, Sebastian C, Ferrer C, Lewis C, Sade-Feldman M, LaSalle T, et al.
Nat Metab
. 2021 Feb;
3(2):182-195.
PMID: 33619381
Head and neck squamous cell carcinoma (SCC) remains among the most aggressive human cancers. Tumour progression and aggressiveness in SCC are largely driven by tumour-propagating cells (TPCs). Aerobic glycolysis, also...
7.
Kowalik M, Puliga E, Cabras L, Sulas P, Petrelli A, Perra A, et al.
J Hepatol
. 2020 Jan;
72(6):1159-1169.
PMID: 31954205
Background & Aims: Only limited therapeutic options are currently available for hepatocellular carcinoma (HCC), making the development of effective alternatives essential. Based on the recent finding that systemic or local...
8.
La Vecchia S, Sebastian C
Semin Cell Dev Biol
. 2019 May;
98:63-70.
PMID: 31129171
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the need for a...
9.
Ioris R, Galie M, Ramadori G, Anderson J, Charollais A, Konstantinidou G, et al.
Cell Rep
. 2017 Feb;
18(8):1858-1868.
PMID: 28228253
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6)....
10.
Sebastian C, Mostoslavsky R
Trends Endocrinol Metab
. 2016 Nov;
28(2):85-87.
PMID: 27863854
Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA...