Jorge L Del-Aguila
Overview
Explore the profile of Jorge L Del-Aguila including associated specialties, affiliations and a list of published articles.
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23
Citations
2052
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Recent Articles
1.
Brase L, You S, DOliveira Albanus R, Del-Aguila J, Dai Y, Novotny B, et al.
Nat Commun
. 2023 Apr;
14(1):2314.
PMID: 37085492
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific effect of variants in these genes...
2.
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila J, Fernandez M, et al.
Sci Rep
. 2023 Jan;
6(1):18092.
PMID: 36647296
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested...
3.
Lananna B, McKee C, King M, Del-Aguila J, Dimitry J, Farias F, et al.
Sci Transl Med
. 2020 Dec;
12(574).
PMID: 33328329
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene , is a widely studied...
4.
Dube U, Del-Aguila J, Li Z, Budde J, Jiang S, Hsu S, et al.
Nat Neurosci
. 2019 Oct;
22(11):1903-1912.
PMID: 31591557
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n = 13; n = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC)....
5.
Li Z, Farias F, Dube U, Del-Aguila J, Mihindukulasuriya K, Fernandez M, et al.
Acta Neuropathol
. 2019 Aug;
139(1):45-61.
PMID: 31456032
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex. The goal of this...
6.
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, et al.
Sci Transl Med
. 2019 Aug;
11(505).
PMID: 31413141
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation, survival, and...
7.
Del-Aguila J, Li Z, Dube U, Mihindukulasuriya K, Budde J, Fernandez M, et al.
Alzheimers Res Ther
. 2019 Aug;
11(1):71.
PMID: 31399126
Background: Alzheimer's disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial...
8.
Del-Aguila J, Benitez B, Li Z, Dube U, Mihindukulasuriya K, Budde J, et al.
Mol Neurodegener
. 2019 May;
14(1):18.
PMID: 31068200
Background: Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2...
9.
Yan Q, Nho K, Del-Aguila J, Wang X, Risacher S, Fan K, et al.
Mol Psychiatry
. 2018 Oct;
26(1):309-321.
PMID: 30361487
Deposition of amyloid plaques in the brain is one of the two main pathological hallmarks of Alzheimer's disease (AD). Amyloid positron emission tomography (PET) is a neuroimaging tool that selectively...
10.
Maxwell T, Corcoran C, Del-Aguila J, Budde J, Deming Y, Cruchaga C, et al.
Alzheimers Res Ther
. 2018 Aug;
10(1):86.
PMID: 30153862
Background: A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait loci (rQTL) are often involved in gene-by-gene (G×G)...