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Maria Victoria Fernandez

Explore the profile of Maria Victoria Fernandez including associated specialties, affiliations and a list of published articles. Areas
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Articles 39
Citations 1378
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Recent Articles
1.
Puerta R, Cano A, Garcia-Gonzalez P, Garcia-Gutierrez F, Capdevila M, de Rojas I, et al.
Int J Mol Sci . 2025 Jan; 26(1. PMID: 39796148
High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan 7k) and antibody-based (Olink...
2.
Morato X, Puerta R, Cano A, Orellana A, de Rojas I, Capdevila M, et al.
Brain Behav Immun Health . 2024 Dec; 42:100899. PMID: 39640195
Despite the central role attributed to neuroinflammation in the etiology and pathobiology of Alzheimer's disease (AD), the direct link between levels of inflammatory mediators in blood and cerebrospinal fluid (CSF)...
3.
Wang C, Yang C, Western D, Ali M, Wang Y, Phuah C, et al.
Nat Genet . 2024 Nov; 56(12):2685-2695. PMID: 39528826
Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals,...
4.
Fernandez M, Liu M, Beric A, Johnson M, Cetin A, Patel M, et al.
Sci Data . 2024 Jul; 11(1):768. PMID: 38997326
The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of...
5.
Seo D, Lee C, Apio C, Heo G, Timsina J, Kohlfeld P, et al.
medRxiv . 2024 Jul; PMID: 38947020
Sex and age are major risk factors for chronic diseases. Recent studies examining age-related molecular changes in plasma provided insights into age-related disease biology. Cerebrospinal fluid (CSF) proteomics can provide...
6.
Cisterna-Garcia A, Beric A, Ali M, Pardo J, Chen H, Fernandez M, et al.
iScience . 2023 Dec; 26(12):108534. PMID: 38089583
There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer's disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic...
7.
Brase L, You S, DOliveira Albanus R, Del-Aguila J, Dai Y, Novotny B, et al.
Nat Commun . 2023 Apr; 14(1):2314. PMID: 37085492
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific effect of variants in these genes...
8.
Cochran J, Acosta-Uribe J, Esposito B, Madrigal L, Aguillon D, Giraldo M, et al.
Alzheimers Dement . 2023 Mar; 19(9):3835-3847. PMID: 36951251
Introduction: Genetic associations with Alzheimer's disease (AD) age at onset (AAO) could reveal genetic variants with therapeutic applications. We present a large Colombian kindred with autosomal dominant AD (ADAD) as...
9.
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila J, Fernandez M, et al.
Sci Rep . 2023 Jan; 6(1):18092. PMID: 36647296
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested...
10.
Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, et al.
Nat Genet . 2022 Nov; 54(12):1786-1794. PMID: 36411364
Alzheimer's disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%. The genetic component of AD has been mainly assessed using genome-wide association studies, which do...