Jorge E Azevedo
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Explore the profile of Jorge E Azevedo including associated specialties, affiliations and a list of published articles.
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64
Citations
1448
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Recent Articles
1.
Francisco T, Pedrosa A, Rodrigues T, Abalkhail T, Li H, Ferreira M, et al.
PLoS Biol
. 2024 Mar;
22(3):e3002567.
PMID: 38470934
PEX5, the peroxisomal protein shuttling receptor, binds newly synthesized proteins in the cytosol and transports them to the organelle. During its stay at the peroxisomal protein translocon, PEX5 is monoubiquitinated...
2.
Lisboa J, Pereira C, Pinto R, Rodrigues I, Pereira L, Pinheiro B, et al.
Nat Commun
. 2023 Nov;
14(1):7431.
PMID: 37973928
Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from endosomes (short-trip) or the endoplasmic...
3.
Ferreira M, Rodrigues T, Pedrosa A, Silva A, Vilarinho B, Francisco T, et al.
Redox Biol
. 2023 Oct;
67:102917.
PMID: 37804696
Despite intensive research on peroxisome biochemistry, the role of glutathione in peroxisomal redox homeostasis has remained a matter of speculation for many years, and only recently has this issue started...
4.
Ferreira M, Rodrigues T, Pedrosa A, Gales L, Salvador A, Francisco T, et al.
Redox Biol
. 2023 May;
63:102764.
PMID: 37257275
Despite the large amounts of HO generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple...
5.
Pedrosa A, Reglinski K, Lismont C, Kors S, Costello J, Rodrigues T, et al.
Histochem Cell Biol
. 2023 May;
159(5):379-387.
PMID: 37160800
No abstract available.
6.
Teixeira A, Loureiro I, Lisboa J, Oliveira P, Azevedo J, Dos Santos N, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982212
subsp. () is a Gram-negative fish pathogen with worldwide distribution and broad host specificity that causes heavy economic losses in aquaculture. Although was first identified more than 50 years ago,...
7.
Ferreira M, Rodrigues T, Pedrosa A, Francisco T, Azevedo J
Methods Mol Biol
. 2023 Mar;
2643:333-343.
PMID: 36952196
Cell-free in vitro systems are invaluable tools to study the molecular mechanisms of protein translocation across biological membranes. We have been using such a strategy to dissect the mechanism of...
8.
Pedrosa A, Francisco T, Rodrigues T, Ferreira M, van der Heden van Noort G, Azevedo J
J Mol Biol
. 2022 Nov;
435(2):167896.
PMID: 36442669
The AAA ATPases PEX1•PEX6 extract PEX5, the peroxisomal protein shuttling receptor, from the peroxisomal membrane so that a new protein transport cycle can start. Extraction requires ubiquitination of PEX5 at...
9.
Ali M, Khan S, Rodrigues T, Francisco T, Jiao X, Qi H, et al.
Hum Genet
. 2021 Jan;
140(4):649-666.
PMID: 33389129
Peroxisomes, single-membrane intracellular organelles, play an important role in various metabolic pathways. The translocation of proteins from the cytosol to peroxisomes depends on peroxisome import receptor proteins and defects in...
10.
Girao H, Okada N, Rodrigues T, Silva A, Figueiredo A, Garcia Z, et al.
J Cell Biol
. 2019 Nov;
219(2).
PMID: 31757788
CLASPs are conserved microtubule plus-end-tracking proteins that suppress microtubule catastrophes and independently localize to kinetochores during mitosis. Thus, CLASPs are ideally positioned to regulate kinetochore-microtubule dynamics required for chromosome segregation...