Jorg Scheuermann
Overview
Explore the profile of Jorg Scheuermann including associated specialties, affiliations and a list of published articles.
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Articles
79
Citations
1450
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0
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Recent Articles
1.
Gloger A, Scheuermann J
Nat Chem Biol
. 2024 Dec;
21(1):20-21.
PMID: 39719495
No abstract available.
2.
Keller M, Petrov D, Gloger A, Dietschi B, Jobin K, Gradinger T, et al.
Science
. 2024 Jun;
384(6701):1259-1265.
PMID: 38870307
The first drugs discovered using DNA-encoded chemical library (DEL) screens have entered late-stage clinical development. However, DEL technology as a whole still suffers from poor chemical purity resulting in suboptimal...
3.
Plais L, Trachsel L, Scheuermann J
Bioconjug Chem
. 2024 Jan;
35(2):147-153.
PMID: 38266192
While dual-display DNA-encoded chemical libraries (DELs) are increasingly employed for ligand discovery, some of their fundamental properties have not yet been studied in-depth. Aided with fluorescence polarization experiments, we demonstrate...
4.
Bisbal Lopez L, Ravazza D, Bocci M, Zana A, Principi L, Dakhel Plaza S, et al.
Front Pharmacol
. 2023 Dec;
14:1320524.
PMID: 38125888
Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the...
5.
Keller M, Schira K, Scheuermann J
Chimia (Aarau)
. 2023 Dec;
76(5):388-395.
PMID: 38069709
DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies....
6.
Puglioli S, Oehler S, Prati L, Scheuermann J, Bassi G, Cazzamalli S, et al.
Chem Sci
. 2023 Nov;
14(43):12026-12033.
PMID: 37969600
DNA-encoded chemical libraries (DELs) are powerful drug discovery tools, enabling the parallel screening of millions of DNA-barcoded compounds. We investigated how the DEL input affects the hit discovery rate in...
7.
Lessing A, Petrov D, Scheuermann J
Trends Pharmacol Sci
. 2023 Sep;
44(11):817-831.
PMID: 37739829
DNA-encoded chemical library technology (DECL or DEL) has become an important pillar for small-molecule drug discovery. The technology rapidly identifies small-molecule hits for relevant target proteins at low cost and...
8.
Ricci F, Schira K, Khettabi L, Lombardo L, Mirabile S, Gitto R, et al.
Eur J Med Chem
. 2023 Sep;
260:115771.
PMID: 37657271
Tyrosinase, a copper-containing enzyme critical in melanin biosynthesis, is a key drug target for hyperpigmentation and melanoma in humans. Testing the inhibitory effects of compounds using tyrosinase from Agaricus bisporus...
9.
Mortensen M, Bertolini M, Mock J, Scheuermann J, Oehler S
Bioconjug Chem
. 2023 Jul;
34(8):1374-1379.
PMID: 37462264
The targeted delivery of bioactive proteins, such as cytokines, for cancer immunotherapy approaches mostly relies on antibodies or antibody fragments. However, fusion proteins may display low tissue penetration due to...
10.
Oehler S, Lucaroni L, Migliorini F, Elsayed A, Prati L, Puglioli S, et al.
Nat Chem
. 2023 Jul;
15(10):1431-1443.
PMID: 37400597
DNA-encoded chemical libraries (DELs) consist of large chemical compound collections individually linked to DNA barcodes, facilitating pooled construction and screening. However, screening campaigns often fail if the molecular arrangement of...