Sebastian Oehler
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Explore the profile of Sebastian Oehler including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
72
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Recent Articles
1.
Puglioli S, Fabbri M, Comacchio C, Alvigini L, De Luca R, Oehler S, et al.
Bioconjug Chem
. 2024 Jul;
35(7):1033-1043.
PMID: 38963407
DNA-Encoded Libraries (DELs) allow the parallel screening of millions of compounds for various applications, including discovery or affinity maturation campaigns. However, library construction and HIT resynthesis can be cumbersome, especially...
2.
Lucaroni L, Oehler S, Georgiev T, Muller M, Bocci M, De Luca R, et al.
Chem Sci
. 2024 May;
15(18):6789-6799.
PMID: 38725500
Prostate-specific membrane antigen (PSMA) is a tumor-associated protein that has been successfully targeted with small organic ligands and monoclonal antibodies. Pluvicto™ is a PSMA-targeted radioligand therapeutic (RLT) recently approved by...
3.
Muller M, Lucaroni L, Favalli N, Bassi G, Neri D, Cazzamalli S, et al.
J Med Chem
. 2024 May;
67(10):8247-8260.
PMID: 38716576
Prostate-specific membrane antigen (PSMA)-targeted radio ligand therapeutics (RLTs), such as [Lu]Lu-PSMA-617 (Pluvicto), have been shown to accumulate in salivary glands and kidneys, potentially leading to undesired side effects. As unwanted...
4.
Puglioli S, Oehler S, Prati L, Scheuermann J, Bassi G, Cazzamalli S, et al.
Chem Sci
. 2023 Nov;
14(43):12026-12033.
PMID: 37969600
DNA-encoded chemical libraries (DELs) are powerful drug discovery tools, enabling the parallel screening of millions of DNA-barcoded compounds. We investigated how the DEL input affects the hit discovery rate in...
5.
Torng W, Biancofiore I, Oehler S, Xu J, Xu J, Watson I, et al.
ACS Omega
. 2023 Jul;
8(28):25090-25100.
PMID: 37483198
DNA-Encoded Chemical Libraries (DELs) have emerged as efficient and cost-effective ligand discovery tools, which enable the generation of protein-ligand interaction data of unprecedented size. In this article, we present an...
6.
Mortensen M, Bertolini M, Mock J, Scheuermann J, Oehler S
Bioconjug Chem
. 2023 Jul;
34(8):1374-1379.
PMID: 37462264
The targeted delivery of bioactive proteins, such as cytokines, for cancer immunotherapy approaches mostly relies on antibodies or antibody fragments. However, fusion proteins may display low tissue penetration due to...
7.
Oehler S, Lucaroni L, Migliorini F, Elsayed A, Prati L, Puglioli S, et al.
Nat Chem
. 2023 Jul;
15(10):1431-1443.
PMID: 37400597
DNA-encoded chemical libraries (DELs) consist of large chemical compound collections individually linked to DNA barcodes, facilitating pooled construction and screening. However, screening campaigns often fail if the molecular arrangement of...
8.
Bassi G, Cazzamalli S, Oehler S, Lucaroni L, Georgiev T, Favalli N, et al.
Eur J Nucl Med Mol Imaging
. 2023 Jun;
50(10):2947-2949.
PMID: 37341746
No abstract available.
9.
Lucaroni L, Georgiev T, Prodi E, Puglioli S, Pellegrino C, Favalli N, et al.
Eur J Nucl Med Mol Imaging
. 2022 Oct;
50(3):957-961.
PMID: 36184692
Purpose: Recently, Pluvicto™ ([Lu]Lu-PSMA-617), a small-molecule prostate-specific membrane antigen (PSMA) radioligand therapeutic, has been approved by the FDA in metastatic castration-resistant prostate cancer. Pluvicto™ and other PSMA-targeting radioligand therapeutics (RLTs)...
10.
Dakhel S, Galbiati A, Migliorini F, Comacchio C, Oehler S, Prati L, et al.
ChemMedChem
. 2022 Aug;
17(21):e202200350.
PMID: 35929380
Natural Killer Group 2D (NKG2D) is a homo-dimeric transmembrane protein which is typically expressed on the surface of natural killer (NK) cells, natural killer T (NKT) cells, gamma delta T...