Joost C van der Horst
Overview
Explore the profile of Joost C van der Horst including associated specialties, affiliations and a list of published articles.
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10
Citations
244
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Recent Articles
1.
Gabba A, Attariya R, Behren S, Pett C, van der Horst J, Yurugi H, et al.
J Am Chem Soc
. 2023 Jun;
145(24):13027-13037.
PMID: 37279388
Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans...
2.
Rodriguez E, Boelaars K, Brown K, Li R, Kruijssen L, Bruijns S, et al.
Nat Commun
. 2021 Feb;
12(1):1270.
PMID: 33627655
Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via...
3.
Cornelissen L, Blanas A, Zaal A, van der Horst J, Kruijssen L, OToole T, et al.
Front Oncol
. 2020 Oct;
10:1622.
PMID: 33014816
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support...
4.
Blanas A, Zaal A, van der Haar Avila I, Kempers M, Kruijssen L, de Kok M, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32927726
Cancer stem cells (CSCs) are located in dedicated niches, where they remain inert to chemotherapeutic drugs and drive metastasis. Although plasticity in the CSC pool is well appreciated, the molecular...
5.
Ilarregui J, Kooij G, Rodriguez E, van der Pol S, Koning N, Kalay H, et al.
J Neuroinflammation
. 2019 Jun;
16(1):130.
PMID: 31248427
Background: Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenesis have...
6.
Sahasrabudhe N, van der Horst J, Spaans V, Kenter G, de Kroon C, Bosse T, et al.
Front Oncol
. 2019 Feb;
9:29.
PMID: 30761272
Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this...
7.
Cornelissen L, Blanas A, van der Horst J, Kruijssen L, Zaal A, OToole T, et al.
Int J Cancer
. 2018 Dec;
144(9):2290-2302.
PMID: 30578646
Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete...
8.
Marcelo F, Supekar N, Corzana F, van der Horst J, Vuist I, Live D, et al.
J Biol Chem
. 2018 Dec;
294(4):1300-1311.
PMID: 30504228
The human macrophage galactose-type lectin (MGL) is a C-type lectin characterized by a unique specificity for terminal GalNAc residues present in the tumor-associated Tn antigen (αGalNAc-Ser/Thr) and its sialylated form,...
9.
Blanas A, Cornelissen L, Kotsias M, van der Horst J, van de Vrugt H, Kalay H, et al.
Glycobiology
. 2018 Nov;
29(2):137-150.
PMID: 30476078
Aberrant fucosylation in cancer cells is considered as a signature of malignant cell transformation and it is associated with tumor progression, metastasis and resistance to chemotherapy. Specifically, in colorectal cancer...
10.
Sahasrabudhe N, Lenos K, van der Horst J, Rodriguez E, van Vliet S
Biol Chem
. 2018 Jun;
399(7):649-659.
PMID: 29894293
Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a...