Jongdoo Lim
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Explore the profile of Jongdoo Lim including associated specialties, affiliations and a list of published articles.
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22
Citations
301
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Recent Articles
1.
Lim J, Guo M, Choi S, Miller S, Anslyn E
Chem Sci
. 2023 Jun;
14(22):5992-5999.
PMID: 37293656
Atropisomeric scaffolds are a common design element found in pharmaceuticals, many deriving from an N-C axis of chirality. The handedness associated with atropisomeric drugs is oftentimes crucial for their efficacy...
2.
Lee J, Coronado J, Cho N, Lim J, Hosford B, Seo S, et al.
Nat Commun
. 2022 Oct;
13(1):6322.
PMID: 36280685
The ribosome is a macromolecular machine that catalyzes the sequence-defined polymerization of L-α-amino acids into polypeptides. The catalysis of peptide bond formation between amino acid substrates is based on entropy...
3.
Lee J, Schwieter K, Watkins A, Kim D, Yu H, Schwarz K, et al.
Nat Commun
. 2019 Nov;
10(1):5097.
PMID: 31704912
The site-specific incorporation of noncanonical monomers into polypeptides through genetic code reprogramming permits synthesis of bio-based products that extend beyond natural limits. To better enable such efforts, flexizymes (transfer RNA...
4.
Lim J, Guan B, Nham K, Hao G, Sun X, Simanek E
Biomolecules
. 2019 Aug;
9(9).
PMID: 31466360
Various glutamate urea ligands have displayed high affinities to prostate specific membrane antigen (PSMA), which is highly overexpressed in prostate and other cancer sites. The multivalent versions of small PSMA-targeted...
5.
Koskela J, Liljestrom V, Lim J, Simanek E, Ras R, Priimagi A, et al.
J Am Chem Soc
. 2014 May;
136(19):6850-3.
PMID: 24785836
This work presents a facile water-based supramolecular approach for light-induced surface patterning. The method is based upon azobenzene-functionalized high-molecular weight triazine dendrimers up to generation 9, demonstrating that even very...
6.
Lee C, Lo S, Lim J, da Costa V, Ramezani S, Oz O, et al.
Mol Pharm
. 2013 Oct;
10(12):4452-61.
PMID: 24134039
The synthesis and characterization of a generation three triazine dendrimer that displays a phenolic group at the core for labeling, up to eight 5 kDa PEG chains for solubility, and...
7.
Lim J, Kostiainen M, Maly J, da Costa V, Annunziata O, Pavan G, et al.
J Am Chem Soc
. 2013 Feb;
135(12):4660-3.
PMID: 23398590
The dendrimer chemistry reported offers a route to synthetic target molecules with spherical shape, well-defined surface chemistries, and dimensions that match the size of virus particles. The largest target, a...
8.
Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics
Lim J, Turkbey B, Bernardo M, Bryant Jr L, Garzoni M, Pavan G, et al.
Bioconjug Chem
. 2012 Oct;
23(11):2291-9.
PMID: 23035964
Four gadolinium (Gd)-based macromolecular contrast agents, G3-(Gd-DOTA)(24), G5-(Gd-DOTA)(96), G3-(Gd-DTPA)(24), and G5-(Gd-DTPA)(96), were prepared that varied in the size of dendrimer (generation three and five), the type of chelate group (DTPA...
9.
Muthukrishnan N, Johnson G, Lim J, Simanek E, Pellois J
Biochim Biophys Acta
. 2012 Jul;
1820(11):1734-43.
PMID: 22771830
Background: Lysis of endocytic organelles is a necessary step in many cellular delivery methodologies. This is achieved efficiently in the photochemical internalization approach but the cell death that accompanies this...
10.
Lim J, Simanek E
Adv Drug Deliv Rev
. 2012 Apr;
64(9):826-35.
PMID: 22465784
The use of triazine dendrimers as drug delivery systems benefits from their synthetic versatility and well-defined structure. Triazine dendrimers can be designed and readily synthesized to display orthogonally functional surfaces...