Jonathan Warrell
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Explore the profile of Jonathan Warrell including associated specialties, affiliations and a list of published articles.
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1532
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Recent Articles
11.
Zhang J, Lee D, Dhiman V, Jiang P, Xu J, McGillivray P, et al.
Nat Commun
. 2020 Jul;
11(1):3696.
PMID: 32728046
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications, it may be advantageous...
12.
Kumar S, Warrell J, Li S, McGillivray P, Meyerson W, Salichos L, et al.
Cell
. 2020 Feb;
180(5):915-927.e16.
PMID: 32084333
The dichotomous model of "drivers" and "passengers" in cancer posits that only a few mutations in a tumor strongly affect its progression, with the remaining ones being inconsequential. Here, we...
13.
Salichos L, Meyerson W, Warrell J, Gerstein M
Nat Commun
. 2020 Feb;
11(1):732.
PMID: 32024824
Tumors accumulate thousands of mutations, and sequencing them has given rise to methods for finding cancer drivers via mutational recurrence. However, these methods require large cohorts and underperform for low...
14.
Rozowsky J, Kitchen R, Park J, Galeev T, Diao J, Warrell J, et al.
Cell Syst
. 2019 Apr;
8(4):352-357.e3.
PMID: 30956140
Small RNA sequencing has been widely adopted to study the diversity of extracellular RNAs (exRNAs) in biofluids; however, the analysis of exRNA samples can be challenging: they are vulnerable to...
15.
Murillo O, Thistlethwaite W, Rozowsky J, Subramanian S, Lucero R, Shah N, et al.
Cell
. 2019 Apr;
177(2):463-477.e15.
PMID: 30951672
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://exrna-atlas.org). The Atlas version 4P1 hosts 5,309...
16.
Wang D, Liu S, Warrell J, Won H, Shi X, Navarro F, et al.
Science
. 2018 Dec;
362(6420).
PMID: 30545857
Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online resource for the adult brain across...
17.
Gandal M, Zhang P, Hadjimichael E, Walker R, Chen C, Liu S, et al.
Science
. 2018 Dec;
362(6420).
PMID: 30545856
Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In...
18.
Warrell J, Mhlanga M
J Theor Biol
. 2016 Nov;
420:304-317.
PMID: 27866978
Coregulation of the expression of groups of genes has been extensively demonstrated empirically in bacterial and eukaryotic systems. Such coregulation can arise through the use of shared regulatory motifs, which...
19.
Manning L, Laman M, Rosanas-Urgell A, Turlach B, Aipit S, Bona C, et al.
PLoS One
. 2012 Nov;
7(11):e48701.
PMID: 23144935
Background: Although rapid diagnostic tests (RDTs) have practical advantages over light microscopy (LM) and good sensitivity in severe falciparum malaria in Africa, their utility where severe non-falciparum malaria occurs is...
20.
Manning L, Laman M, Law I, Bona C, Aipit S, Teine D, et al.
PLoS One
. 2012 Jan;
6(12):e29203.
PMID: 22216212
Background: Mortality from severe pediatric falciparum malaria appears low in Oceania but Plasmodium vivax is increasingly recognized as a cause of complications and death. The features and prognosis of mixed...